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首页> 美国政府科技报告 >Chemokine Receptors and Integrin Function in Prostate Cancer
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Chemokine Receptors and Integrin Function in Prostate Cancer

机译：趋化因子受体和整合素在前列腺癌中的作用

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Changes in prostate tumor cell adhesion are important considerations in the progression, invasion and metastasis of prostate cancer. The originally funded studies focused on evaluating the effects of chemokines, which are chemotactic cytokines, on the activation of prostate carcinoma adhesion and migration. The results demonstrated that a specific chemokine, termed IL-8, stimulated the migration and adhesion of advanced prostate carcinoma cells. The purpose of the proposal was to further define the importance of IL-S in the activation of integrins, which are major adhesion molecules that mediate prostate carcinoma migration and invasion. During the course of these studies, we attempted to develop a model in which we could evaluate the effects of IL-S on adhesion of prostate cancer cells to endothelial cells. In these studies, we included both large vessel endothelial cells and bone marrow endothelial cells, in an attempt to determine if IL-S might stimulate adhesion of prostate tumor cells to substrates other than basement membrane components. The bone marrow endothelial cell line was chosen because of the preferential metastasis of prostate cancer to bone. During the course of these studies, we discovered a novel mechanism by which prostate carcinoma cells could adhere to bone marrow endothelial cells. This mechanism involved the elaboration of a specific glycosaminoglycan termed hyaluronan by prostate tumor cells. These studies were further developed to establish the importance of hyaluronan expression in prostate tumor cell adhesion, growth and vascularization. A summary of these findings is also included in the final report.

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