目的：观察中西医结合治疗支气管扩张症稳定期患者的临床疗效。方法选取2012年6月-2013年6月同济大学附属上海市肺科医院呼吸科、肺内科就诊的支气管扩张症稳定期患者120例，采用随机数字表法分为对照组和治疗组，各60例，对照组给予盐酸氨溴索片治疗，治疗组在盐酸氨溴索片治疗基础上给予三拗片，疗程为3个月。观察两组临床疗效，比较治疗前后两组患者临床症状体征积分（咳嗽、咳痰、咯血、发热、呼吸困难、胸闷胸痛、湿啰音）、圣乔治呼吸问卷（SGRQ）评分。结果治疗后对照组临床控制10例、显效22例、有效17例、无效11例，治疗组临床控制18例、显效29例、有效10例、无效3例，两组临床疗效比较，差异有统计学意义（u =2.950，P =0.003）。治疗前，两组患者咳嗽、咳痰、咯血、发热、呼吸困难、胸闷胸痛、湿啰音临床症状体征积分比较，差异均无统计学意义（P >0.05）；治疗后，治疗组咳嗽、咳痰、咯血、呼吸困难、胸闷胸痛、湿啰音临床症状体征积分较对照组降低（P <0.05），且治疗组 SGRQ 评分及其中的症状、活动、影响评分较对照组降低（P <0.05）。结论三拗片联合盐酸氨溴索能显著改善支气管扩张症稳定期患者的临床症状，提高其生活质量。%Objective To observe the clinical efficacy of combined therapy of traditional Chinese and western medicine in treatment of patients with bronchiectasis in stable period. Methods 120 patients with bronchiectasis in stable period who visi-ted pulmonary medicine and Department of Respiration of Shanghai Pulmonary Hospital Affiliated to Tongji University from June 2012 to June 2013,were selected as study subjects,by random number table method,the cases were randomly divided into treatment group and control group with 60 cases in each group. The cases in treatment group were treated with the ambroxol hydro-chloride tablets and San'ao tablets,while the cases in control group were treated with only ambroxol hydrochloride tablets. Treat-ments in both two groups lasted for three months. The indicators reflecting clinical efficacy of two groups,including scores of clin-ical symptoms and signs(cough,sputum,hemoptysis,fever,dyspnea,chest distress and chest pain,moist crackles)before and after treatment, and scores of St. George' s respiratory from questionnaire ( SGRQ ), were compared between two groups. Results After treatment,the numbers of clinical control,remarkable effect,effect,and inefficacy were 10,22,17, and 11 in control group,respectively,while the numbers of clinical control,remarkable effect,effect,and inefficacy were 18, 29,10,3 in treatment group,respectively. There was significant difference in the clinical efficacy between two groups ( u = 2. 950,P = 0. 003). Before treatment,there was no significant difference in scores of clinical symptoms and signs(cough, sputum,hemoptysis,fever,dyspnea,chest distress and chest pain,and moist crackles)between two groups(P > 0. 05). After treatment,scores of clinical symptoms and signs( cough,sputum,hemoptysis,difficulty breathing,chest distress and chest pain,and moist crackles)in treatment group were significantly lower than those in control group(P < 0. 05). And SGRQ score,scores of symptom,activity and influentce in treatment group were significantly lower than those in control group(P <0. 05). Conclusion San'ao tablets combined with ambroxol hydrochloride tablets can significantly improve the clinical symp-toms of patients with stable bronchiectasis and enhance their life quality.
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