Objective To investigate the relationship between schizophrenia and metabolic syndrome( MS). Meth-ods Make retrospective analysis of the related data of 773 cases were chosen from the 2 899 schizophrenics hospitalized in mental health center of the second people's hospital in Lu'an city during June 2012 to June 2013 and according to Chinese Diabetes Soci-ety(CDS)criterion for MS,2004,that is whether with concurrent metabolic syndrome(MS)or not,were divided into MS and non-MS groups. Self-designed questionnaire was used for comparisons of the data of the two groups including gender,age, hospital stay,course of the disease,types of antipsychotic drugs,fasting plasma glucose( FPG),triglycerides( TG),high-density lipoprotein cholesterol ( HDL-C ), blood pressure ( BP ), body mass index ( BMI ) and number of years of smok-ing. Results The prevalence of 773 schizophrenia patients with metabolic syndrome was 40. 8%(315/773). FPG,TG,BMI and BP levels of patients in MS group were higher than those in non-MS group,while HDL-C level was lower(P<0. 01). There was no difference of the prevalence rate of schizophrenics with MS between men(161/409,39. 4%)and women(154/364,42. 3%)(P>0. 05). The prevalence rate of MS in patients who aged>50(42/77,54. 5%)was higher than those aged<30(83/222,37. 4%)and aged 30 to 50(190/474,40. 1%)(P<0. 05). The patients who didn't smoke had a low-er prevalence rate(162/456,35. 5%)than the patients with history of smoking less than 10 years(50/100,50. 0%)and more than 10 years(103/217,47. 5%)(P<0. 05). Patients with more than 10 years of disease course had a higher preva-lence rate(128/271,47. 2%)than those with 5 to 10 years(125/330,37. 9%)and less than 5 years(62/172,36. 0%) (P<0. 05). Different sorts of antipsychotic drugs could affect the incidence of MS in varying degrees,but there was no differ-ence(P>0. 05). The multi-factor logistic regression analysis shows that gender,age,smoking history,course of schizophre-nia were correlated with MS. Conclusion Patients with schizophrenia have a higher prevalence of MS compared with general pop-ulation,especially the female and the ones who are with old ages,longer smoking history and course of the disease. Antipsychotic treatment is also a risk factor for metabolic syndrome.%目的：探讨精神分裂症与代谢综合征（ metabolic syndrome，MS）的关系。方法于2013年9—12月从六安市第二人民医院精神卫生中心2012年6月—2013年6月收治住院的2899例精神疾病患者中，抽取符合纳入、排除标准的773例。据2004年中华医学会糖尿病分会（ CDS，2004） MS诊断标准，按是否合并MS将其分为MS组和无MS组。采用自制一般情况调查表，分别对两组患者的性别、年龄、住院天数、病程、抗精神病药物种类、空腹血糖（ FPG）、三酰甘油（ TG）、高密度脂蛋白胆固醇（ HDL-C）、血压（ BP）、体质指数（ BMI）及吸烟史等资料进行比较。结果773例精神分裂症患者中有40.8%（315/773）合并MS。MS组患者的FPG、TG、BMI及血压水平高于无MS组，HDL-C水平低于无MS组，差异有统计学意义（ P<0.01）。精神分裂症患者MS的患病率比较，男性患者的患病率（161/409，39.4%）和女性患者的患病率（154/364，42.3%）差异无统计学意义（P>0.05）；>50岁的患者的患病率（42/77，54.5%）高于<30岁（83/222，37.4%）和30~50岁（190/474，40.1%）的患者，差异有统计学意义（P<0.05）；无吸烟史患者的患病率（162/456，35.5%）低于吸烟史<10年（50/100，50.0%）和≥10年的患者（103/217，47.5%），差异有统计学意义（P<0.05）；病程>10年的患者的患病率（128/271，47.2%）高于病程<5年（62/172，36.0%）和5~10年的患者（125/330，37.9%），差异有统计学意义（P<0.05）。使用不同抗精神病药物的患者MS的患病率各不相同，但差异无统计学意义（ P>0.05）。多因素回归分析显示，性别、年龄、吸烟史及精神分裂症病程对精神分裂症是否合并MS的影响有统计学意义（ P<0.05）。结论精神分裂症患者MS的患病率较一般人群要高，尤其是女性、年龄大、吸烟及病程长的患者，使用抗精神病药物也可能是导致 MS发病的危险因素。
展开▼
