To observe the effect of Alprostadil injection combined with Danshen injection in the treatment of early diabetic nephropathy. Methods 120 patients with early diabetic nephropathy were randomly divided into Alprostadil group ( 60 cases ) and combined treatment group ( 60 cases ) . All the patients were given diabetes diet, blood sugar control and blood pressure control as well as blood fat adjustment. The Alprostadil group was given Alprostadil injection ( 20 μg, once/day )The combined treatment group was given Alprostadil injection ( 20 μg, once/day ) and Danshen injection ( 20 ml, once/day ). The course of treatment was four weeks. The changes of total cholesterol ( TC ), triglyeride ( TG ), high density lipoprotein ( HDL - C ), low density lipoprotein ( LDL - C ), blood urea nitrogen ( BUN ), serum creatinine ( Cr ), urinary albumin excretion rate ( UAER ) and p, - MG in the two groups were observed before the treatment and after the four weeks treatment. Results The levels of TC, TG, LDL - C, Cr, BUN, UAER and p, - MG- in the two groups were all significantly decreased after treatment ( P < 0. 05 ), while the level of HDL - C was significantly increased after treatment ( P < 0. 05 ) . The improvement level of the above mentioned parameters was significantly better in the combined treatment group than in the Alprostadil group ( P <0. 05 ) . Conclusion Combined treatment of Alprostadil injection and Danshen injection is effective in the treatment of early diabetic nephropathy.%目的 观察前列地尔注射液联合丹参注射液治疗早期糖尿病肾病(DN)的疗效.方法 将120例早期DN患者随机分为两组:前列地尔组(60例)和丹参注射液+前列地尔联合治疗组(联合治疗组,60例).两组患者均接受糖尿病饮食、降糖、控制血压及调脂治疗;前列地尔组另静脉滴注前列地尔注射液(20 μg,1次/d);联合治疗组另静脉滴注前列地尔注射液(20 μg,1次/d)及丹参注射液(20 ml,1次/d),总疗程4周.观察治疗前及治疗4周后两组患者血脂[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]、血尿素氮(BUN)、肌酐(Cr)、尿清蛋白排泄率(UAER)、β2微球蛋白(β2-MG)的变化.结果 两组患者治疗后血脂(TC、TG、LDL-C)、Cr、BUN、UAER、β2-MG均较治疗前显著下降(P＜0.05),HDL-C较治疗前显著升高(P＜0.05);治疗后联合治疗组患者上述指标改善程度显著高于前列地尔组,差异均有统计学意义(P＜0.05).结论 前列地尔注射液联合丹参注射液能够有效治疗早期DN.
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