目的 探讨β-七叶皂苷钠联合甘露醇治疗重型颅脑损伤的临床疗效.方法 将我院2009年6月-2011年6月收治的60例重型颅脑损伤患者随机分为治疗组(30例)及对照组(30例),对照组给予20%甘露醇、营养神经及预防感染等常规治疗,治疗组在此基础上加用β-七叶皂苷钠进行降颅内压(ICP)治疗,比较两组治疗后ICP及治疗前后格拉斯哥昏迷评分(GCS)变化情况,并于治疗后3、6个月进行格拉斯哥预后评分(GOS).结果 治疗组治疗后ICP及GCS与对照组比较,差异有统计学意义(P＜0.05);治疗后3个月及6个月两组GOS比较,差异均有统计学意义(P＜0.05).结论 β-七叶皂苷钠与甘露醇联合应用治疗重型颅脑损伤可起到理想效果,两药合用不仅能够明显降低颅内压,而且对早期GCS及远期GOS都有明显改善.%To study the clinical efficacy of p - aescine sodium combined with mannitol in the treatment of severe brain injury. Methods 60 patients with severe brain injury admitted to our hospital from June 2009 to June 2011 were randomly divided into treatment group ( 30 cases ) and control group ( 30 cases ) . The control group was routinely given 20% mannitol, neurotrophic and anti - infection treatment. While the treatment group was given β - aescine sodium in addition to reduce in-tracranial pressure ( ICP ) . The ICP before the treatment and Glasgow Coma Scale ( GCS ) before and after the treatment of the two groups were compared. Glasgow Outcome Scale ( GOS ) was conducted three and six months after treatment respectively. Results The ICP and GCS in the treatment group showed statistically significant differences compared with control group after-treatment ( P<0. 05) . The three - month and six - month after treatment showed that the difference of GOS between treatment group and control group was also statistically significant ( P < 0.05 ) . Conclusion The efficacy of β - aescine sodium combined with mannitol in the treatment of severe brain injury is satisfactory, can significant reduce the intracranial pressure, and improve the results of short - term GCS and long - term GOS.
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