To observe the clinical efficacy and safety of nifedipine controlled release tablets ( NCRT) and valsartan in the treatment of type 2 diabetic nephropathy ( DN ) and hypertension in elderly patients. Methods 62 elderly patients with type 2 DN and hypertension were randomly divided into NCHT group ( 20 cases ), valsartan group ( 20 cases ) and combined treatment group ( 22 cases ) . The three groups were all given hypoglycemic drug per os or subcutaneous injection of insulin , and they were given antihypertensive drugs after blood glucose reached target level. Patients in NCRT group and valsartan group were given 30 mg NCRT and 80 mg valsartan once a day, while patients in combined treatment group were given 30 mg NCRT and 80 mg valsartan once a day. The course of treatment was six months. The blood pressure, 24 h UAER and changes of renal function of the three groups were observed before and after treatment. Results After treatment, the blood pressure and 24 h UAER of combined treatment group were significantly lower than those of the NCRT group and valsartan group ( P < 0. 05 ) .No adverse reactions were found during treatment. Conclusion The combination of NCRT and valsartan in the treatment of type 2 DN and hypertension in elderly patients shows efficacy superior to single drug with satisfactory safety.%目的 观察硝苯地平控释片联合缬沙坦治疗老年2型糖尿病肾病(DN)合并高血压的临床疗效及安全性.方法 将62例老年2型DN合并高血压患者随机分为硝苯地平控释片组(20例)、缬沙坦组(20例)及联合治疗组(22例).3组患者均口服降糖药或皮下注射胰岛素,血糖达标后口服降压药物治疗.硝苯地平控释片组、缬沙坦组患者分别给予硝苯地平控释片30mg、缬沙坦80 mg,1次/d;联合治疗组给予硝苯地平控释片30 mg+缬沙坦80 mg,1次/d.疗程为6个月.观察治疗前后3组患者血压、24h尿微量清蛋白排泄率(UAER)和肾功能变化.结果 治疗后联合治疗组患者血压及24 h UAER均显著低于硝苯地平控释片组和缬沙坦组,差异有统计学意义(P均＜0.05);治疗过程中3组均未见明显不良反应.结论 硝苯地平控释片联合缬沙坦治疗老年2型DN合并高血压效果优于单独用药,且较为安全.
展开▼
