目的 探讨初发2型糖尿病(T2DM)患者胰岛素抵抗(IR)与血小板参数的相关性.方法 检测90例住院或门诊的初发T2DM患者和90例健康体检者(对照组)的血压、血小板参数[包括血小板计数(PLT)、血小板平均体积(MPV)和血小板体积分布宽度(PDW)]、空腹血糖(FBG)、空腹胰岛素(FINS)、血脂[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]等指标.结果 (1)初发T2DM组患者FBG 、TC、TG 、MPV 及 PDW 均显著高于对照组(P＜0.05).(2)T2DM患者中,IR组患者FBG、胰岛素抵抗指数(HOMA-IR)、TC、TG、MPV及PDW均显著高于非IR组(P＜0.05);T2DM组患者中MPV与HOMA-IR呈正相关(r=0.351,P=0.03);(3)IR组在IR改善后FBG、HOMA-IR 、TG、MPV、PDW较治疗前均显著下降(P＜0.05).结论 初发T2DM患者的血小板活性增强,改善IR可降低血小板活性,对防治糖尿病血管并发症有益.%Objective To investigate the relationship between insulin resistance and the platelet parameters in newly diagnosed type 2 diabetic patients. Methods Blood press, the platelet parameters [ including blood platelets count ( PLT ),mean platelet volume ( MPV ), and platelet distribution width ( PDW) ], fasting blood glucose (FBG), fasting insulin, blood lipid [triglyceride ( TG), total cholesterol ( TC ), high density lipoprotein cholesterol ( HDL - C ), low density lipoprotein cholesterol ( LDL - C ) ] were determined in 90 patients with newly diagnosed type 2 diabetes and 90 healthy controls. Results Levels of FBG, TG, TC , MPV, and PDW in the newly diagnosed type 2 diabetic patients were significantly higher than those in healthy controls ( P＜0.05 ). Among T2DM patients, levels of FBG, HOMA - IR, TG, TC, MPV, and PDW in the insulin resistance group were significantly higher than those in the non - insulin resistance group ( P ＜ 0.05 ); MPV level was positively correlated with HOMA -IR ( r = 0.351, P = 0.03 ) . Levels of FBG, HOMA - IR, TG, MPV, and PDW significantly decreased in the insulin resistance group after treatment in comparison with before ( P ＜ 0.05 ) . Conclusion The activity of platelet is enhanced in newly diagnosed type 2 diabetic patients, which could he reduced by improvement of the insulin resistance status.
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