目的 探讨胃特安片对阿司匹林所致大鼠胃黏膜损伤的作用及其对还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)含量的影响.方法 选取Sprague-Dawley大鼠30只,随机分为阿司匹林模型组、胃特安治疗组和对照组.阿司匹林模型组用10.41 mg/kg阿司匹林灌胃1次/d.胃特安治疗组用阿司匹林10.41 mg/kg灌胃,1次/d;胃特安片200 mg/kg灌胃,3次/d.对照组给予0.9%氯化钠溶液灌胃.4周后用Guth评分和Whittle评分分别比较各组大鼠胃黏膜损伤情况,检测胃黏膜组织中GSH、SOD、MDA含量.结果 与对照组比较,阿司匹林模型组大鼠Guth评分和Whittle评分均显著增高,胃黏膜GSH含量显著降低,MDA含量显著升高,差异均有统计学意义(P＜0.05);与阿司匹林模型组比较,胃特安治疗组大鼠Guth评分和Whittle评分均显著降低,GSH含量显著升高,而MDA含量显著降低,差异均有统计学意义(P＜0.05).3组大鼠胃黏膜SOD含量比较差异无统计学意义(P＞0.05).结论 小剂量阿司匹林可致大鼠胃黏膜损伤,胃特安片具有增强胃黏膜抗氧化作用和细胞保护作用.%Objective To explore protective effects of Weitean on gastric mucosal lesions induced by aspirin in rats and the contents of GSH, SOD and MDA. Methods Thirty Sprague - Dawley rats were divided into model group , therapy group and control group. Model group was treated with aspirin ( 10.41 mg/kg qd ), therapy group was treated with aspirin ( 10.41 mg/kg qd ) and Weitean ( 200 mg/kg tid ), and control group physiological saline. Contents of GSH, SOD and MDA were detected 4 weeks later, when gastric mucosal lesions were evaluated by Gutt and Whittle methods respectively. Results Compared with the control group, Guth scores and Whittle scores of the model group were higher than those of the control group ( P ＜ 0.05 ) . The content of GSH decreased and the content of MDA increased significantly in the model group in comparison with the control control ( P＜0.05 ) . Guth and Whittle scores of the therapy group were lower than those of the model group ( P ＜ 0.05 ) . Content of GSH increased and content of MDA decreased significantly in the therapy group in comparison with the model group ( P ＜ 0.05 ).SOD content among the three groups showed no significant differences ( P ＞ 0.05 ) . Conclusion Low dose of aspirin may cause gastric mucosal damage which can be counteracted by Weitean.
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