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首页> 外文期刊>RSC Advances >Protective effect of Artemisia campestris extract against aspirin-induced gastric lesions and oxidative stress in rat
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Protective effect of Artemisia campestris extract against aspirin-induced gastric lesions and oxidative stress in rat

机译：香蒿提取物对阿司匹林诱发的大鼠胃黏膜损伤和氧化应激的保护作用

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摘要

The present study aims at evaluating the antiulcer and antioxidant effect of Artemisia campestris aqueous extract (ACAE) as well as the mechanism of action involved in such gastroprotection. The use of LC/MS allowed the identification of 11 phenolic compounds and the colorimetric analysis demonstrated that the ACAE exhibited an important in vitro antioxidant activity. We first showed that in vivo ACAE protected against macroscopic and histological changes induced by aspirin in stomach mucosa. Aspirin administration was accompanied by an oxidative stress status assessed by an increase in malondialdehyde (MDA) level, a decrease in the content of sulfhydryl -(SH) groups and a depletion of antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Pre-treatment with ACAE protected against aspirin-induced gastric oxidative stress. More importantly, aspirin administration increased plasma and tissue hydrogen peroxide (H2O2), free iron and calcium levels, while the ACAE pre-treatment reversed all the effects of aspirin-induced intracellular mediators. In conclusion, we suggest that Artemisia campestris aqueous extract has potent antiulcer and antioxidant properties. This gastroprotection offered by ACAE might be related partly to the safety of sulfhydryl group as well as its opposite effect on some intracellular mediators such as hydrogen peroxide, free iron and calcium.
机译：本研究旨在评估青蒿水提取物（ACAE）的抗溃疡和抗氧化作用，以及参与这种胃保护作用的机制。 LC / MS的使用可以鉴定11种酚类化合物，比色分析表明ACAE具有重要的体外抗氧化活性。我们首先表明，体内ACAE可以防止阿司匹林在胃粘膜中引起的宏观和组织学变化。服用阿司匹林会伴随氧化应激状态的发生，该状态通过丙二醛（MDA）含量的增加，巯基-（SH）基团的含量的减少以及抗氧化酶活性（如超氧化物歧化酶（SOD），过氧化氢酶（CAT））的消耗来评估）和谷胱甘肽过氧化物酶（GPx）。用ACAE进行预处理可防止阿司匹林引起的胃氧化应激。更重要的是，服用阿司匹林可增加血浆和组织中的过氧化氢（H2O2），游离铁和钙的水平，而ACAE预处理则可以逆转阿司匹林诱导的细胞内介质的所有作用。总之，我们建议蒿蒿水提物具有有效的抗溃疡和抗氧化特性。 ACAE提供的这种胃保护作用可能与巯基的安全性及其对某些细胞内介质（例如过氧化氢，游离铁和钙）的相反作用有关。

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