Objective To evaluate the prevalence and genotypes of human papillomavirus (HPV) in anal and oral region in men who have sex with men (MSM) in Shanghai. Methods A total of 162 MSM with condyloma acuminatum in anal region were enrolled in this study. The samples were collected from the anal region and oral and the HPV genotypes were analyzed. Results Among 162 patients,77.85% of them were multiple HPV-infected, and the majority of multiple HPV-infected were superinfection (24.69%,40/162) and triple infection (32.10%,52/162). The high-risk HPV genotype in the anal area was 53.09% (86/162), among those, the rank of HPV genotype was HPV52(17.28%), HPV33(17.28%) and HPV16(15.43%). The positive rate of HPV in oral area was 36.42%. Patients with oral condyloma acuminatum were seen in 10 patients (6.17%,10/162). Compared to the samples from anal region, there were not significantly correlated with the detection rate of single-type infection, superinfection or triple HPV infection. The highest infection rate of high-risk HPV genotypes in oral were HPV16, HPV52, HPV33, HPV31 and HPV58, which distribution was more dispersed. Conclusion The prevalence of HPV infection in oral was high in those with anal condyloma acuminatum patients in Shanghai. The HPV high-risk type in oral and anal canal is different, indicating that the oral HPV infection should be dragged attention. Early diagnosis of HPV infection and use of HPV vaccine can effectively prevent and control HPV infection and the resulting sexually transmitted diseases, as well as the occurrence of related tumors.%目的 调查上海地区男男性行为者(MSM)肛门部位[包括肛周和(或)肛管]尖锐湿疣(CA)与口腔部位人类乳头瘤病毒(HPV)的感染情况和亚型特征.方法 对上海市皮肤病医院性病门诊2013年10月至2017年1月期间就诊的肛门尖锐湿疣的MSM人群进行入组,采集病史及相关部位的脱落细胞样本,进行HPV基因型别分析.结果 入组的162例研究对象,肛门部位尖锐湿疣部位HPV以多重型别感染最为常见,占63.58%(103/162),绝大多数为二重感染(24.69%,40/162)和三重感染(32.10%,52/162).肛门部位高危型别HPV的感染率为53.09%(86/162).各高危型别HPV的检出率较高的依次为HPV52型(17.28%)、HPV33型(17.28%)和HPV16型(15.43%).口腔部位HPV感染阳性检出率为36.42%(59/162),合并口腔尖锐湿疣患者10例(6.17%,10/162).口腔部位与肛周肛管CA部位HPV检出率相比,单一型别、二重型别和三重型别HPV感染均有差异(P<0.05).与肛周、肛管尖锐湿疣部位HPV优势高危型相比,口腔部位阳性检出率较高的HPV感染型别除了16型、52型和33型,还有31型和58型,高危型分布较分散.结论 上海地区MSM肛周或肛管尖锐湿疣者的口腔部位HPV感染率较高,且口腔部位HPV高危型别与肛门部位有差异,因此需加强对口腔HPV感染情况的重视.HPV感染的早期诊治和HPV疫苗的预防性接种,能有效的预防和控制HPV感染及其导致的性传播疾病及相关肿瘤的发生.
展开▼
