Objective To investigate the related factors to clinical pregnancy rate of intrauterine insemination with husband sperm. Methods The pregnancy outcome of 320 IUI cycles of 130 infertile couples were retrospectively analyzed according to the age of infertile couples, the duration of infertility periodicity, the cause of infertility ,ovulation induction protocol and total forward movement sperm (TMS). Results Thirty-five cases acquired pregnancy in 130 infertile couples. The accumulation pregnancy rate was 26.9%.The periodicity pregnancy rate was 10.9%. The age of infertile couples, the duration of infertility, the number of periodicity were significantly lower in patients who acquired pregnancy than the patients who did not (P<0.05). Dysspermia, ovulation failure,fallopian tubes factors and endometriosis infertility were leading four causes for infertility. There were not significant differences in the pregnancy rate among four groups (P>0.05). The pregnancy rate of natural and ovarian stimulation period were 7.1%and 16.1%respectively (P<0.05). The pregnancy rate of primary infertility and secondary infertility were 28.6%and 24,5%respectively(P>0.05). The pregnancy rate in patients with TMS 5×106~10×106;10×106~20×106,≥20×106 were2.7%, 8.3%, 13.0%respectively. There were not significant differences among these three group (P>0.05). Conclusion The age of infertile couples, the duration of infertility, the number of periodicity and ovulation induction protocol were important factors influencing on clinical pregnancy rate of IUI. Male dysspermia and ovulation failure treated by IUI could acquire good pregnancy rate. TMS have some influence on the pregnancy rate.%目的：探讨影响夫精宫腔内人工授精（IUI）临床妊娠率的相关因素。方法回顾性分析本生殖中心130对不孕夫妇进行的320个治疗周期，对男女方年龄、不孕年限、周期数、不孕病因、用药方案、注入宫腔内的前向运动精子数和妊娠结局的关系进行分析。结果130对不孕夫妇共获得临床妊娠35例，临床累积妊娠率26.9%，周期妊娠率10.9%。妊娠夫妇双方年龄、不孕年限、授精周期显著低于未妊娠夫妇（P＜0.05）。男方精液异常、女方排卵障碍、输卵管因素、子宫内膜异位症的不孕患者占周期总数的前4位，但4组受孕率比较差异无统计学意义（P＞0.05）。自然周期、促排卵周期妊娠率分别为7.1%，16.1%，两者比较差异有统计学意义（P＜0.05）；原发不孕妊娠率28.6%，继发不孕妊娠率24.5%，两组比较差异无统计学意义（P＞0.05）。处理后的前向运动精子数分为三组，分别为5×106~10×106和10×106~20×106；＞20×106，妊娠率分别为2.7%，8.3%和13.0%，三组间的妊娠率比较无统计学意义（P＞0.05）。结论男女方年龄、不孕年限、周期数和用药方案是影响IUI结局的重要因素。男方精液异常和女方排卵障碍行IUI能获得较好妊娠率。注入宫腔的前向运动精子数对妊娠率有一定影响。
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