目的 评价辣椒辣素类似物(RTX)治疗早泄的临床疗效.方法 自2008年10月至2009年10月门诊就诊的早泄患者,共41例,其中RTX治疗组中有包皮过长的早泄患者11例,单纯早泄患者10例;安慰剂治疗组中有包皮过长的早泄患者10例,单纯早泄患者10例.平均年龄23岁.两组患者在性交前1h分别使用100nmol/L的RTX溶液和纯酒精溶液30ml局部浸泡阴茎头30min.4周后记录治疗前后早泄患者CIPE-5评分、射精潜伏期(ILET)和治疗期间的不良反应.结果 治疗组早泄合并包皮过长患者中,治愈1例,改善6例,有效率为63.6%;治疗组单纯早泄患者中,改善2例,有效率20%,总有效率42.9%.有效率比较差异有统计学意义(P<0.05).而安慰剂治疗的早泄患者,总的治愈率15%,有效率比较差异没有统计学意义(P>0.05).治疗组早泄合并包皮过长患者治疗前后IELT和CIPE-5分别为(1.29±0.46)min、(11.82±5.19)分和(4.55±4.05)min、(16.00±4.22)分,治疗前后比较差异有统计学意义(P<0.05),治疗组单纯早泄患者治疗前后IELT和CIPE-5分别为(0.89±0.37)min、(11.80±4.52)分和(1.43±1.44)rain、(12.40±5.32)分,治疗前后比较差异没有统计学意义(P>0.05).治疗组合并包皮过长的早泄患者和单纯早泄患者治疗后IELT和ClFE-5比较,差异有统计学意义(P<0.05).而安慰剂治疗的早泄患者IELT和CIPE-5在治疗前后均差异没有统计学意义(P>0.05).两组患者在局部浸泡治疗过程中均不同程度表现为阴茎头的刺痛感,均可忍受,治疗后1h内疼痛感逐渐消失.结论 初步研究表明,RTX可以作为有包皮过长的早泄患者的一种治疗方法.%Objective To evaluate the efficacy of resiniferatoxin in the treatment of patients with premature ejaculation. Methods From October of 2008 to October of 2009,total of 41 outpatients with premature ejaculation were analyzed. The mean age of patients was 23 years. In the patients treated with RTX there were 11 cases premature ejaculation with redundant prepuce and 10 without redundant prepuce. In the patients treated with placebo,there were 10 cases premature ejaculation with redundant prepuce and 10 without redundant prepuce. An hour before sexual intercourse, glans were respectively soaked in 30ml of RTX with a concentration of 100 nmol/l and pure alcohol for 30 minutes. Four weeks later, the CIPE-5, the intravagina ejaculation latency (ILET) and the side effects of the patients were recorded. Results In patients with premature ejaculation treated with RTX, 1 case of them was cured and 6 cases were improved. The effective rate was 63.6％. And for 10 premature ejaculation patients without redundant prepuce, only 2 cases were improved. The effective rate was only 20％, and the total effective rate was 42.9％. These was significant difference in effective rate between two groups (P＜0.05). Whereas for patients with premature ejaculation treated by placebo, the total effective rate was 15％, no difference was found in the effective rate(P＞0.05). For premature ejaculation patients with redundant prepuce, the average ILET and CIPE-5 were(l.29±0.46)min and(11.82±5.19), (4.55±4.05)min and (16.00±4.22) respectively before and after treatment (P＜0.05). For premature ejaculation patients without redundant prepuce, the average ILET and CIPE-5 were(0.89±0.37)min and(11.80±4.52), (1.43±1.44)ain and (12.40±5.32) respectively before and after treatment (P＞0.05). There were significant differences in IELT and CIPE-5 after treatment between premature ejaculation patients with redundant prepuce and without redundant prepuce (P＜0.05). Wherea for those patients with premature ejaculation treated by placebo, no difference was found in IELTand CIPE-5 before and after treatment (P＞0.05). All patients felt pains of glans during soaking in RTX, and an hour later they had no pain feelings. Conclusion These results indicated that resiniferatoxin (RTX) might be suitable for the treatment of patients with premature ejaculation and redundant prepuce.
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