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首页> 美国政府科技报告 >Vitamin D3 and Vitamin D3 Analogs as Protectants Against the Cardiotoxicity of Chemotherapeutic Agents Utilized in the Treatment of Breast Cancer
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Vitamin D3 and Vitamin D3 Analogs as Protectants Against the Cardiotoxicity of Chemotherapeutic Agents Utilized in the Treatment of Breast Cancer

机译：维生素D3和维生素D3类似物作为防治化疗药物心脏毒性的保护剂用于治疗乳腺癌

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Studies were performed to determine whether 1,25 dihydroxy vitamin D, the active form of this hormone, could protect cardiomyocytes from the toxicity of chemotherapy and radiation. Studies were performed in two models of cardiomyocyte function, H9c2 and HL1 cardiomycoytes. However, 1, 25 dihydroxy vitamin D3 failed to protect against either radiation, adriamycin (doxorubicin) or paclitaxel. We also tested sildenafil as a cardioprotectant, as this phosphodiesterase-5 inibitor has been shown to suppress ischemia -reperfusion injury to the heart. However, neither sildenafil alone nor sildenafil in combination with vitamin D demonstrated significant protection. Subsequent studies indicated that the toxicity of radiation may be related to the promotion of autophagy. In the course of this work, we developed an animal model of radiation induced cardiac injury and studies are ongoing to evaluate other cardioprotective strategies, such as the use of IL-1.

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