目的 探讨养精赞育颗粒治疗弱精子症患者对精子DNA完整性的影响.方法 选择弱精子症患者86例,口服养精赞育颗粒3个月.通过吖啶橙试验(AOT)与计算机辅助精液分析(CASA)检测DFI(精子DNA断裂指标)和精液常规参数.再将86例患者按照DFI值(大于10%或小于10%)进行分层研究并使用SPSS11.5软件进行数据分析.结果 治疗3个月后,a级精子百分比和(a+b)精子百分比与治疗前相比差异均有统计学意义(P<0.01);所有86例患者DFI绝对值(6.89±4.08)与治疗前(11.31±7.21)相比差异有统计学意义(P<0.01);DFI正常组DFI绝对值(4.71±1.87)与治疗前(5.25±2.61)相比差异无统计学意义(P>0.05);DFI异常组DFI绝对值(8.61±4.53)与治疗前(16.11±5.94)相比差异有统计学意义(P<0.01).结论 应用养精赞育颗粒治疗男性不育可显著改善精子的活力和精子DNA的完整性;补脾益肾是提高精子DNA完整性的有效方法 .%Objective To investigate the effects of Yangjingzanyu granula on sperm DNA integrity of patients with asthenospermia. Methods Eighty-six patients with asthenospermia were enrolled in the study and treated with Yangjingzangyu granula for three months. Sperm DFI was detected by AO Test Assay, semen routine parameters were measured by CASA. All the cases were divided into two groups based on the value of DFI more than 10%. Result There were significant differences in the perecnt of A and (A+B) sperm between before and after treatment (P<0. 01); There were also significant differences in DFI for all the patients or abnormal DFI group between before and after treatment(l1.31±7.21)%vs(6.89±4.08)%, P<0.01; (16.1 l±5.94)%vs(8.61±4.53)%, P<0.01).But no significant difference in DFI was found for normal DFI group [DFI(5.25±2.61)% vs (4.71±1.87%), P>0.05]. Conclusion Yangjingzanyu granula might effectively improve the sperm motility and the sperm DNA integrity, reduce sperm DFI of asthenospermia. Tonifying spleen and invigorate kidney might be a effective method to improve the integrity of sperm DNA.
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