Objective To evaluate the clinical efficacy of daily small dose Vardenafil and Trazodone combining with psychotherapy and physical training on treatment of premature ejaculation(PE). Methods Total of 136 patients with PE were randomly divided into two groups such as experimental group (small dose Vardenafil and Trazodone combining with behavior therapy) and control group (trazodone combining with behavior therapy). Intra-vaginal ejaculation latency times(IELT) of patients were detected and the coitus satisfaction of patients and their spouses were recorded before and after treatment. Results The IELTs of two groups were (0.87±0.29) and (0.93±0.35) minutes respectively before treatment, and (4.62±2.31) and (2.35±1.25) minutes respectively after treatment. There was a significant difference in IELTs between before treatment and after treatment (P＜0.01), furthermore there was also a significant difference in IELTs between experimental group and control group(P＜0.01).For satisfaction degree of sex life, better results were found in experimental group (62.3%) in comparison with that of control group (37.3%), (P＜0.01). Total satisfaction rate (satisfaction and basic satisfaction) was 89.8% and 67.2% in experimental group and control group, which existed a significant difference (P＜0.01).%目的 探讨持续小剂量伐地那非联合曲唑酮并配合心理行为治疗早泄的临床疗效.方法 136例早泄患者随机分为实验组(小剂量伐地那非+曲唑酮+行为疗法)和对照组(曲唑酮+行为疗法),记录治疗前后阴道内射精潜伏期(IELT)并进行组内和组间比较,同时记录夫妻对性生活的满意情况.结果 治疗前,实验组和对照组IELT分别为(0.87±0.29)min、(0.93±0.35)min,治疗后分别为(4.62±2.31)min、(2.35±1.25)min,差异有统计学意义(P＜0.01),且实验组IELT较对照组相比差异有统计学意义(P＜0.01).夫妻双方对性生活的情况:实验组满意率(62.3%)和总满意率(满意加基本满意)(89.8%)分别优于对照组满意率(37.3%)和总满意率(67.2%),差异均有统计学意义(P＜0.01).结论 持续小剂量伐地那非联合曲唑酮并配合心理行为治疗早泄在延长IELT,改善夫妻双方性生活满意度方面明显优于盐酸曲唑酮配合心理行为疗法组,持续小剂量给药可以起到增强疗效和降低副作用,两药合用在治疗早泄方面有一定的应用前景.
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