"Cold remedies heat,and hot remedies coldness" is one of the main treating methods in the Traditional Chinese Medicine.Pungent,containing in most of herbs can activate the Thermo-TRPs in order to remove either excessive heat or coldness as well as to relieve pains.These herbs' desensitization to the channels may be the principle of this treating method in a cellular and molecular biological point of view.%“寒者热之,热者寒之”是重要的中医治疗大法之一.许多寒热药物具有辛味,这些辛辣成分能激活热敏通道,发挥清热、散寒或止痛的作用.这些药物脱敏热敏通道,可能是“寒者热之,热者寒之”的细胞和分子生物学原理.
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