Objective: To explore the effect of DHDB on NO/NOS expression levels and calcium homeostasis in brain tissue of aging model rats. Methods: The subacutely aging model rats were made by injecting D-gal into abdominal cavity continually, and NO、NOS、Ca2+ -ATPase and Ca2+ levels in brain tissue were evaluated. Results: The NO, NOS and Ca2+levels in model group were downregulated ( P ＜ 0.05 ), Ca2 + -ATPase levels in that was increased significantly ( P ＜0.05). After treated with DHDB, NO, NOS and Ca2 + levels were upregulated ( P ＜ 0.05 ) , Ca2 + levels was reduced significantly (P ＜ 0.05 ). Conclusions: The results demonstrated that DHDB can regulate metabolism of NO, NOS and Calcium Homeostasis in brain tissue.%目的:探讨郭煌大宝胶囊对衰老模型大鼠脑组织NO/NOS表达水平及钙平衡的影响.方法:采用D-半乳糖建立大鼠衰老模型,测定各组大鼠脑组织内NO/NOS表达水平、Ca~2-ATPas.活性以及Ca~2含量.结果:模型组大鼠脑组织内NO/NOS水平、Ca~2+含量显著升高(P <0.05),Ca~2+-ATPase活性显著降低(P<0.05);经郭煌大宝胶囊治疗后,大鼠脑组织内NO/NOS水平、Ca~2+含量显著降低(P < 0.05),Ca~2+-ATPase活性显著升高(P<0.05).结论:郭煌大宝胶囊具有调节衰老大鼠脑组织NO/NOS表达水平以及钙平衡的作用.
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