Objective: to research the antipyretic mechanisms of Buzhongyiqitang in reserpine-induced splenasthenic rabbit. Method: The model of splenasthenic syndrome in rabbit was made by i. m. reserpine. Then, Buzhongyiqitang groups were given Buzhongyiqitang 5g/kg, 10g/kg to stomach. On the 4th day,observing the changes of temperature, PGE2 in cerebrospinal fluid and cAMP in hypothalamus-preoptic tissue between model group, control group and Buzhongyiqitang groups after i.v. TAB triple-vaccine. Results: Buzhongyiqitang can remarkably reduce elevated temperature ( P < 0.01, P< 0.01), PGE2 and cAMP. Conclusion: Buzhongyiqitang had antipyretic effect for reserpine-induced splenasthenic syndrome with elevated temperature in rabbit. The mechanism is probably" related to reducing PGE2 and cAMP in concerned central nervous.
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