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首页> 外文期刊>Life sciences >Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats
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Changes of body temperature and extracellular serotonin level in the preoptic area and anterior hypothalamus after thermal or serotonergic pharmacological stimulation of freely moving rats

机译：热或血清素能药理刺激自由移动大鼠后视前区和下丘脑前区的体温和细胞外血清素水平的变化

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Although many studies has been shown that serotonin (5-HT) in the preoptic area and anterior hypothalamus (PO/AH) is important for regulating body temperature (Tb), the exact role is not established yet due to conflicting results probably related to experimental techniques or conditions such as the use of anesthesia. The purpose of present study was to clarify the role of 5-HT in the PO/AH using the combined methods of telemetry, microdialysis and high performance liquid chromatography (HPLC), with a special emphasis on the regulation of Tb in freely moving rats. Firstly, we measured changes in Tb and levels of extracellular 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HLAA) in the PO/AH during cold (5degreesC) and heat (35degreesC) exposure. We also perfused fluoxetine (5-HT re-uptake inhibitor) and 8-hydroxy-2-(Di-n-propylamino)tetralin (8-OH-DPAT: 5-HT1A agonist) into the PO/AH. During both exposures, although Tb changed significantly, no significant changes were noted in extracellular levels of 5-HT and 5-HIAA in the PO/AH. In addition, although perfusion of fluoxetine or 8-OH-DPAT into the PO/AH increased or decreased extracellular 5-HT and 5-HIAA levels in the PO/AH respectively, but Tb did not change at all. Our results suggest that 5-HT in the PO/AH may not mediate acute changes in thermoregulation. (C) 2004 Elsevier Inc. All rights reserved.
机译：尽管许多研究表明，视前区和下丘脑前部（PO / AH）的5-羟色胺（5-HT）对于调节体温（Tb）很重要，但由于与实验有关的结果相互矛盾，因此尚未确定确切的作用麻醉等技术或条件。本研究的目的是使用遥测，微透析和高效液相色谱（HPLC）的组合方法阐明5-HT在PO / AH中的作用，特别着重于自由运动大鼠中Tb的调节。首先，我们测量了冷（5℃）和热（35℃）暴露期间PO / AH中Tb和细胞外5-HT及其代谢物5-羟基吲哚乙酸（5-HLAA）水平的变化。我们还将氟西汀（5-HT再摄取抑制剂）和8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT：5-HT1A激动剂）灌注到PO / AH中。在两次暴露期间，尽管Tb发生了显着变化，但PO / AH中细胞外5-HT和5-HIAA的水平未见明显变化。此外，尽管在PO / AH中灌注氟西汀或8-OH-DPAT分别增加或降低了PO / AH中细胞外5-HT和5-HIAA的水平，但Tb完全没有改变。我们的结果表明，PO / AH中的5-HT可能不会介导温度调节的急性变化。 （C）2004 Elsevier Inc.保留所有权利。

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