目的 探讨卡介菌多糖核酸联合阿达帕林凝胶治疗扁平疣的效果及对细胞免疫功能的影响.方法 选取2015年1月~2016年5月在本院治疗的扁平疣患者100例,将患者随机分为观察组和对照组,每组50例.对照组给予阿达帕林凝胶治疗,观察组在对照组治疗基础上给予卡介菌多糖核酸,比较两组治疗效果.结果 观察组治疗总有效率为84.0%(42/50),对照组为60.0%(30/50),观察组治疗效果明显优于对照组(P<0.05),;观察组治疗后皮损积分为(4.22±1.05)分,明显低于对照组(P<0.05);对照组治疗前后T细胞亚群比较差异无统计学意义;观察组治疗后lgG和lgM较治疗前升高(P<0.05);观察组和对照组不良反应率分别为14.0%(7/50)和18.0%(9/50),比较差异无统计学意义.结论 卡介菌多糖核酸联合阿达帕林凝胶治疗扁平疣疗效较好,能改善患者体液免疫功能,且安全可靠.%Objective To investigate effect of BCG polyose nuclear acid combined with adapalene Gel in the treatment of flat wart.MethodsFrom January 2015 to May 2016, 100 flat wart patients were selected in our hospital, the patients were divided into observation group and control group, each group 50 cases, the control group was given Adapalene Gel therapy, the treatment group was treated with BCG polyose nuclear acid on the basis of control group, the therapeutic effect of the two groups were observed.ResultsThe total effective rate of the treatment group was 84.0%(42/50), and the control group was 60.0%(30/50)The treatment effect of observation group was significantly better than the control group (P< 0.05);The skin lesion score of observation group after treatment was (4.22±1.05) scores, which was significantly lower than that in the control group (P< 0.05);There was no significant difference in T lymphocyte subsets between the observation group and the control group;After treatment, the lgG and lgM in observationgroup were higher than before treatment (P< 0.05);The adverse reaction rates of the observation group and the control group were 14.0%(7/50) and 18.0%(9/50), the difference was not statistically significant.ConclusionThe therapeutic effect of BCG polyose nuclear acid combined with adapalene gel in the treatment of flat wart is better, it can improve the humoral immune function of patients, and it is safe and reliable.
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