从半合成原料、菌种选育及改良和生物转化新技术与新工艺(包括底物的物理/化学助溶法,新型转化体系和细胞通透性改良法)等方面对近几年来甾体生物转化进展进行综述.可以预测,在甾体药物的工业化生产过程中,生物转化技术所占比例将大幅度提高.%Progress of biotransformation technology of steroid compounds was reviewed. The selection of steroid raw materials, selection and improvement of microbial strain and new technologies of biotransformation were discussed, including physical/chemical solubilizing of substrates, new transformation system and improvement of cell permeability. It is forecasted that the proportion of biotransformation technologies increased in the industrial production process of steroid hormone drugs.
展开▼
