Purpose To investigate the expression and clinical significance of DOG-1 and C-erbB-2 in papillary thyroid carcinoma.Methods Immunohistochemical SP method was used to detect the expression of DOG-1 and C-erbB-2 protein in 48 cases of papillary thyroid carcinoma and 30 cases of benign thyroid lesions (15 cases of nodular goiter and 15 cases of Hashimoto's thyroiditis).Results The DOG-1 positive rate of thyroid papillary carcinoma (27.08％,13/48) was significantly higher than that of benign lesions (0,0/30),the difference was significant (P ＜ 0.05).The C-erbB-2 positive rate (39.58％,19/48) was significantly higher than that of benign lesions (3.33％,1/30),the difference was significant (P ＜ 0.05).Positive expression of DOG-1 as well as C-erbB-2 correlated with advanced TNM and presence of lymph node metastasis.The expression of DOG-1 and C-erbB-2 in patients with multifocal carcinomas combined with lymphatic metastasis showed a significant positive correlation(r =0.503,P =0.024).Conclusion The data suggest that DOG-1 and C-erbB-2 contribute to the pathogenesis and progress of thyroid papillary carcinoma.Our results introduce DOG-1 combined with C-erbB-2 as a promising biomarker for recurrence prediction and target therapy.%目的 探讨甲状腺乳头状癌(papillary thyroid carcinoma,PTC)组织中DOG-1和C-erbB-2的表达及临床意义.方法 采用免疫组化SP法检测48例PTC和30例甲状腺良性病变(结节性甲状腺肿15例、桥本甲状腺炎15例)中DOG-1和C-erbB-2蛋白的表达.结果 PTC中DOG-1的阳性率(27.08％,13/48)明显高于甲状腺良性病变(0,0/30),两者差异有显著性(P＜0.05).C-erbB-2的阳性率(39.58％,19/48)也明显高于甲状腺良性病变(3.33％,1/30),两者差异有显著性(P＜0.05).DOG-1、C-erbB-2的表达均与患者临床分期、淋巴结转移明显相关;在多灶且有淋巴结转移病例中DOG-1与C-erbB-2的表达呈显著正相关(r =0.503,P=0.024).结论 DOG-1及C-erbB-2的表达与PTC的转化、进展密切相关,联合检测可以作为判断PTC的生物学行为、评估其复发风险的重要指标,并为靶向治疗提供可能性.
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