Purpose To investigate the clinicopatholgical features and pathogenesis of Brunner' s gland hamartoma( BGH ). Methods The clinico-pathological features were analyzed in 7 cases of BGH. and the literature was reviewed. Reasults The mean age of the patients of BGH was 53. 6 years ( ranger from 25 to 80 years ). The common clinical manifestations were abdominal pain, ahdominal distention , gastrointestinal hemorrhage, duodenal obstruction, constipation and so on. The more common location is the posterior wall of the duodenum of the hulbar zone and descending part with the appearance of polypoid, solid, cystic. Microscopically, the hyperplastic Brunner' s gland were separated by bundles of smooth muscle cells. with the duct dilated, cyst, adipose cell in it. Focal lymphocytes infiltration were found frequently in the tumor. Conclusions BGH is a rare kind of benign lesion of duodenal. Pathological morphological features are the key point of diagnosis and differential diagnosis of this disease.%目的 探讨Brunner腺错构瘤(Burnner's gland hamartoma, BGH)的临床病理特征及发病机制.方法 收集7例BGH临床及病理资料,进行病理形态学观察,并复习相关文献.结果 BGH发病年龄平均53.6岁(25～80岁),临床表现腹痛、腹胀、黑便、肠梗阻、便秘等症状;常发生在十二指肠球部、降部,外观呈息肉状,实性或囊性;光镜下表现为Brunner腺结节状增生,被平滑肌束分隔呈小叶状,伴有导管扩张、囊肿、脂肪细胞,常见灶性淋巴细胞浸润等.结论 BGH是十二指肠罕见的良性疾病,诊断和鉴别诊断主要依据病理形态学特征.
展开▼
