目的 观察血液透析对重症急性胰腺炎患者的治疗效果,并试图探讨其治疗重症急性胰腺炎可能的作用机制.方法 将入选的52例重症急性胰腺炎患者随机分为治疗组(A组)和对照组(B组).治疗组的患者除常规治疗外,同时给予隔日1次的血液透析,检测患者的血清C-反应蛋白、内毒素和白细胞介素-8(IL-8)的水平以评价炎症变化情况.结果 重症急性胰腺炎患者血清C-反应蛋白、内毒素和IL-8均显著高于正常.与对照治疗组相比,治疗组血清C-反应蛋白、内毒素和IL-8的下降趋势均显著增快,且治疗组临床症状显著改善.结论 血液透析可促进急性胰腺炎患者尽早恢复,清除体内炎性细胞因子及内毒素,减轻炎症反应,从而改善内毒素血症是其可能的作用机制.%Objective To investigate the effect and mechanism of hemodialysis on severe acute pancreatitis in human. Methods 52 patients were randomly divided into two groups. Except the routine therapy,the patients were given hemodialysis e. o. d. in the therapy group. The C-reaction protein in blood, endotoxin and IL-8 on the first, third,fifth and seventh day in both groups were measured,and was evaluated the change of inflammation. Results The C-reaction protein in blood. Endotoxin and IL-8 in both therapy groups were much higher than that in normal control groups. In the therapy group,the C-reaction protein in blood,endotoxin and IL-8 deceased more quickly than that in control therapy group. The patients also recuperated more quickly than the control therapy group. Conclusion Hemodialysis can inhibit the progression of acute pancreatitis, clear away the cytokine and endotoxin, reduce inflammation, than promote amelioratea copremia.
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