Objective To research the correlation between cervical cancer and squamous intraepithelial lesion with the imbalance of vaginal microenvironment.Methods A total of 318 outpatients were assigned into two groups,of which 159 women diagnosed with cervical cancer or squamous intraepithelial lesion by pathology were selected as experimental group,and the other 159 women without cervical lesions were selected as control group.Results The detection rates of HPV,BV,AV,trichomonas of experiment group were 88.05%,39.62%,33.33% and 13.21% respectively,which significantly higher than those in control group (P<0.05).Proportion of experiment group with level III-IV of vaginal cleanliness,pH value exceed 4.5,level I or IV of flora diversity and H2O2 positive were 50.31%,55.35%,59.75% and 72.33% respectively,which were significantly higher than those in control group (P<0.05).Conclusion Pathogen infection in vagina may increase the possibility of cervical lesions.Imbalance of Vaginal microenvironment may be one of the important factors of cervical lesions.%目的 探讨阴道微环境改变与宫颈病变的相关性.方法 选取门诊就诊妇女为研究对象.根据病理学结果分组,研究组159例为宫颈组织病理学结果提示宫颈癌和低级别、高级别鳞状上皮内病变患者,对照组159例为宫颈组织病理学结果正常就诊者.检测两组研究对象阴道分泌物中人类乳头瘤病毒(HPV)、病原体及阴道微生态指标,结合病理结果进行比较分析.结果 研究组中HPV、细菌性阴道病、需氧型阴道炎、滴虫检出率分别为88.05%、39.62%、33.33%和13.21%,明显高于对照组(P<0.05).研究组患者阴道分泌物清洁度III-IV度、pH>4.5、菌群多样性异常(I、IV级)和过氧化氢阳性的比例分别为50.31%、55.35%、59.75%和72.33%,显著高于对照组(P<0.05).结论 阴道内病原体感染可能增加宫颈病变发生,阴道微环境改变是参与宫颈病变发生发展的重要因素之一.
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