目的 观察左西孟旦对急性失代偿心力衰竭患者心功能、QRS波时相和C反应蛋白(CRP)的影响.方法 将111例急性失代偿心力衰竭患者按照随机数字表法分为研究组56例和对照组55例.两组均予标准常规治疗.研究组加用左西孟旦.治疗7d后观察两组血浆脑利钠肽(BNP)、左室射血分数(LVEF)、心电图QRS波时相、CRP的变化,判断疗效及不良反应.结果 两组治疗前血浆BNP、LVEF、QRS波时相、CRP比较差异均无统计学意义(P＞0.05),治疗后血浆BNP、LVEF、QRS波时相、CRP均较治疗前明显改善(P＜0.05),且左西孟旦组改善更明显,差异均有统计学意义(P＜0.05).左西孟旦组总有效率明显高于对照组[91.1％(51/56)比76.4％ (42/55)],差异有统计学意义(P＜0.05).结论 左西孟旦可显著改善急性失代偿心力衰竭患者的症状,QRS波时相缩短,CRP下降,提高心功能,安全性好.%Objective To observe the effects of levosimendan on the acute decompensated heart failure,the QRS duration and C-reaction protein.Methods 111 cases of patients with acute decompensated heart failure were randomly divided into experimental group with 56 cases and control group with 55 cases.The two groups were both given conventional treatment and the experimental group was added with levosimendan treatment.The plasma brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),QRS duration and C-reaction protein changes after 7ds of two groups were observed,the curative effect and adverse reaction were evaluated.Results The total effective rate of the levosimendan group was significantly higher than that of the control group [91.1％ (51/56) VS.76.4％ (42/55)],the difference was statistically significant (P ＜ 0.05).Plasma BNP,LVEF,QRS duration and CRP the two groups were not significant differences before treatment (P ＞ O.05).The two groups plasma BNP,LVEF,QRS duration and CRP of two groups were significantly improved and the levosimendan group was more obviously improved after treatment,and the differences were statistically significant (P ＜ 0.05).Conclusion Levosimendan can significantly improve cardiac function in patients with acute decompensated heart failure,shorten QRS duration and decrease CRP with good safety.
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机译：左西孟旦对急性失代偿性心力衰竭患者短期临床病程的影响。 RE Amive心力衰竭研究小组的J Am Coll Cardiol HF M.PackerW.ColucciL.Fisher左西孟旦对急性失代偿性心力衰竭患者短期临床病程的影响。 J Am Coll Cardiol HF12013103111
