Objective To explore the correlation of montreal cognitive assessment (MoCA)and S100βprotein、Homocysteine(Hcy)in patients of chronic cerebral circulation insufficiency (CCCl)with cognitive impairment.Methods Forty -eight patients with CCCl were as CCCl group,while 46 healthy subjects were as control group.The cognitive function and the level of S100βprotein、Hcy were detected.Results The incidence (72.91%,35 /48)of cognitive impairment of CCCl group was significantly higherthan control group (21.73%,10 /46)(P <0.01).The concentration of S100βprotein and Hcy of CCCl group was higher than control group (P <0.05).The MoCA score of CCCl group was negative relationship with S100βprotein and Hcy.No relationship was found between S100βprotein and Hcy.Conclu-sions Patients with CCCI have a higher incidence of cognitive impairment.S100βprotein and Hcy are important risk factors of CCCl occurrence.S100βprotein and Hcy maybe the separate risk factors of cognitive impairment.%目的：探讨 S100β蛋白、同型半胱氨酸（Hcy）水平与慢性脑供血不足（CCCI）患者认知功能水平的相关性。方法选择48例 CCCI 患者作为 CCCI 组，46例健康体检者作为健康对照组，对 CCCI 组和健康对照组进行综合检测评分，认知功能水平检测采用蒙特利尔认知评估量表（MoCA），并进行血液指标 S100β蛋白及Hcy 检测。结果 CCCI 组患者认知功能障碍发生率为72．91％（35／48），明显高于健康对照组的发生率21．73％（10／46）（P ＜0．01）。CCCI 组 S100β蛋白、Hcy 含量均高于健康对照组（P ＜0．05）。CCCI 组 S100β蛋白、Hcy含量与 MoCA 评分呈负相关（P ＜0．05）；S100β蛋白、Hcy 未见明显线性相关（P ＞0．05）。结论 CCCI 组患者认知功能障碍发生率高；S100β蛋白、Hcy 可能参与 CCCI 的发生和发展；S100β蛋白、Hcy 可能是影响 CCCI 患者认知功能的2个相互独立的因素。
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