Objective To study the clinical application of MIF in the diagnosis of elderly nephrotic syndrome patients with cerebral infarction.Methods Clinical data of 84 patients with nephrotic syndrome were analyzed,ne-phrotic syndrome patients with cerebral infarction as the observation group,patients with nephrotic syndrome as con-trol group.MIF were measured by ABC-ELISA.Results The TG in the observation group was significantly higher than that in control group(t =2.792,P =0.007).No significant difference was found between the two groups in TC, HDL and LDL-C (P >0.05).Serum Hcy (t =2.601,P =0.011),MIF (t =2.973,P =0.004),and hs-CRP(t =2.143,P =0.035)in the observation group were higher than those in control group,a statistically significant differ-ence (P <0.05).TG had a positive correlation with Hcy (r =0.365,P =0.020),MIF(r =0.477,P =0.002), hs-CRP(r =0.357,P =0.024)in observation group.When the MIF value was 0.856 μg/L,the sensitivity of the di-agnosis of nephrotic syndrome with cerebral infarction was 92.52%,specificity was 88.64%.Conclusions MIF can be used as a effective index in the clinical diagnosis of nephrotic syndrome patients with cerebral infarction.%目的：研究巨噬细胞移动抑制因子（MIF）在老年肾病综合征合并脑梗死患者判断价值与临床应用。方法分析84例肾病综合征患者的临床资料，将其中合并患有脑梗死的40例患者列为观察组，仅患有肾病综合征的44例患者划为对照组。采用双夹心酶联免疫吸附试验测定 MIF 在老年肾病综合征合并脑梗死患者的血清水平。结果观察组患者血清中三酰甘油（TG）含量明显高于对照组，差异有统计学意义（t＝2．792，P ＝0．007），两组研究对象在总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）水平比较上，差异无统计学意义（P ＞0．05）；观察组患者血清中同型半胱氨酸（Hcy）（t ＝2．601，P ＝0．011）、MIF（t ＝2．973，P ＝0．004）、超敏 C 反应蛋白（hs-CRP）（t ＝2．143，P ＝0．035）指标水平高于对照组，差异有统计学意义（P ＜0．05）；观察组患者 TG 与 Hcy（r ＝0．365，P ＝0．020）、MIF（r ＝0．477，P ＝0．002）、hs-CRP（r ＝0．357，P ＝0．024）呈正相关；当 MIF 取值为0．856μg／L 时对肾病综合征合并脑梗死的诊断敏感性为92．52％，特异性为88．64％。结论 MIF 可以作为判诊断肾病综合征合并脑梗死患者的有效指标。
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