目的：探讨 N-末端脑钠肽原对急性心力衰竭诊断的价值。方法选择就诊的急性心力衰竭的患者106例，另选对照组52例，来源于同期因胸闷、气喘、呼吸困难就诊的患者，临床诊断排除急性心力衰竭，分别测定血浆 N-末端脑钠肽原浓度，比较不同组患者的血浆 N-末端脑钠肽原水平。结果≥75岁人群中，急性心力衰竭组 N-末端脑钠肽原（88．41±14．72）pmol／L 与对照组 N-末端脑钠肽原（33．27±6．61）pmol／L 比较，t ＝18．57，P ＜0．05。＜75岁人群中，急性心力衰竭组 N-末端脑钠肽原（32．73±5．97）pmol／L 与对照组 N-末端脑钠肽原（6．12±2．51）pmol／L 比较，t ＝27．28，P ＜0．05。结论急性心力衰竭患者 N-末端脑钠肽原明显升高，N-末端脑钠肽原对急性心力衰竭诊断有意义。%Objective To explore the value of N-terminal brain natriuretic peptide in the diagnosis of acute heart failure.Methods A total of 158 patients with dyspnea were selected,including 106 patients with acute heart fail-ure and 52 controls and 52 controls with other diease.The N-terminal brain natriuretic peptide were measured and com-pared.Results The N-terminal brain natriuretic peptide of acute heart failure[(88.41 ±14.72)pmol/L ]was signifi-cantly higher than that of the control group[(33.27 ±6.61)pmol/L]in people aged 75 years or older (t =18.57,P <0.05).The N-terminal brain natriuretic peptide of acute heart failure[(32.73 ±5.97)pmol/L]was significantly higher than that of the control group[(6.12 ±2.51)pmol/L](t =27.28,P <0.05).Conclusion The N-terminal brain natri-uretic peptide is significantly increased in patients with acute heart failure,N-terminal brain natriuretic peptide detection has some diagnose value in patients with acute heart failure.
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