目的了解短期胰岛素强化治疗对初诊断2型糖尿病患者胰岛α细胞及β细胞功能的影响。方法选取初诊断的2型糖尿病患者30例，对入选的患者给予胰岛素强化治疗（甘精胰岛素＋三餐前速效人胰岛素类似物或胰岛素泵），治疗前后均行C肽释放试验（馒头餐试验），检测空腹、餐后半小时及餐后2h的胰高血糖素、C肽及静脉血糖值。结果与强化治疗前相比，患者各时点静脉血糖明显下降，强化治疗后HOMA-IR指数均有显著降低（P＜0．05），而HOMA-β指数显著升高（P＜0．05），C肽血糖净增比（△CP30/△G30，△CP120/△G120）均有上升（P＜0．05），各时点CP/胰高血糖素比显著升高（P＜0．05）；结论胰岛素短期强化治疗对初诊断的2型糖尿病患者的β细胞及α细胞功能均有改善作用，并能部分改善胰岛素抵抗。%Objective To observe the changes of αand βislet cell function by short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes Mellitus (T2DM).Methods 30 patients with newly diag-nosed with T2DM were selected.The patients were allocated to receive intensive insulin therapy (insulin glargine and short-acting insulin analogues /insulin pump before each meal ) .C-peptide test ( steamed bread meal test ) was per-formed before and after treatment for all patients .The level of glucagon ,C-peptide and venous blood glucose were de-tected at the time of fasting,0.5h and 2 h after the meal.Results The levels of venous blood glucose at different time point and HOMA-IR were decreased after the intensive treatment (p<0.05),while the index of HOMA-βwere signif-icantly increased (p<0.05).The ratio of △CP30/△G30,△CP120/△G120 and CP/glucagon at each time point were increased (p<0.05),Conclusion Short-term intensive insulin therapy could improve the function of αandβislet cell in patients with newly diagnosed T 2DM.
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