目的 观察阿托伐他汀对大鼠急性心肌梗死后心室重塑和心功能的影响.方法 20只雄性SD大鼠通过前降支动脉结扎法建立大鼠急性心肌梗死模型后随机分为心肌梗死组(AMI),阿托伐他汀组(ATV),另设假手术组,每组n=10.阿托伐他汀组每天给予阿托伐他汀钙片(10 mg·kg-1·d-1)灌胃,持续4周.假手术组和心肌梗死组每天给予同等量的0.9％氯化钠注射溶液灌胃.治疗前后分别测量3组大鼠的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)和短轴缩短率(LVFS).大鼠处死后,测量左心室重量及左心重量指数.采用羟胺氧化法测定大鼠血清超氧化物歧化酶活力(SOD).采用TBA法测定血清丙二醛(MDA)水平.结果 治疗4周后,与正常组比较,心肌梗死组和阿托伐他汀组的左心室重量及左心室重量指数均显著增加.与心肌梗死组比较,阿托伐他汀组的左心室重量及左心室重量指数均显著降低,LVEDD、LVESD明显降低,LVEF显著升高.血清超氧化物歧化酶活力显著增强,血清丙二醛水平下降.结论 阿托伐他汀可能通过抗氧化作用,改善心肌梗死后大鼠心室重构和左心室功能,防治心室重塑.%Objective To investigate the effect of atorvastatirt on the cardiac function and left ventricular remodeling in rats with acute myocardial infarction. Methods 20 male SD Rats were modeled by left anterior descending artery ligation,then they were randomly divided into AMI group and AMI + atorvastatin group (ATV group). 10 male SD rats were sham-operated. Rats in ATV group were treated with atorvastatin gavage (l0mg/Kg/day) everyday, lasting for 4 weeks. In AMI group and sham-operated group rats were treated with drinking water. SOD and MDA were detected. The cardiac function were measured by echocardiographic examination. Results After four weeks,left ventricular mass and LVMI of AMI group and ATV group were significantly increased compared with sham group. Compared with AMI group, left ventricular mass and LVMI of ATV group were significantly decreased. LVEDD and LVESD significantly decreased and LVEF increased. The level of SOD increased and MDA decreased. Conclusion Atorvastatin may inhibit left ventricular remodeling and improve cardiac function of rats with myocardial infarction, which may be related to its effect in scavering the oxygen free radicals.
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