Objective To observe the changes of B-type natriuretic peptide (BNP)and central venous pressure (CVP) in the elderly patients who received albumin infusion. Methods A total of 48 elderly patients receiving albumin. Plasma BNP and CVP were measured before infusion or 24 hours and 5 days after infusion. Results ① The level of plasma BNP measured 24 hours after infusion was significantly higher (295.86 ± 193.52 pg/ml) than those measured before infusion ( 150.82 ±74.90 pg/ml,P ＜0.01 ). ② CVP measured 24 hours after infusion were significantly higher (14.09 ± 2.55cm H2 O)than those measured before infusion (12.08 ± 2.24 cm H2 O,P ＜ 0.01 ). There was a significant correlation between plasma BNP and CVP(r =0.46,P =0.015). ③ The levels of BNP in ＞90 years old group were higher than those in 80 ～90 years old group measured in 24 hours after infusion ( P ＜0.01 )and in 5 days after infusion (P ＜ 0.05 ). Conclusion Plasma BNP and CVP could valuably reflect the loading volume of colloid solution in elderly patients.%目的 通过观察80岁以上患者应用人血白蛋白前后B型钠尿肽(BNP)、中心静脉压(CVP)的变化及相关性,了解胶体溶液对老年人心脏容量负荷的影响.方法 入选80岁以上低蛋白血症患者48例,接受人血白蛋白10 g静脉注射治疗,在用药前、用药后24 h分别测定BNP及CVP,并于用药后5 d复查BNP.结果 ①患者用药前血浆BNP为(150.82±74.90) pg/ml,用药后24 h明显升高至(295.86±193.52) pg/ml(P＜0.01).用药后5 d BNP为(168.25±109.20) pg/ml,较用药后24 h明显下降(P＜0.01).②患者用药前、用药后24 h CVP由(12.08±2.24) cmH2O升至(14.09±2.55) cmH2O(P＜0.01).线形回归分析显示用药后CVP与BNP呈正相关(r=0.46,P=0.015).③年龄＞90岁组用药后24 h 血浆BNP明显高于80～90岁组(P＜0.01＝,用药5 d后＞90岁组BNP仍明显高于80～90岁组(P＜0.05＝.结论 应用白蛋白对BNP、CVP进行测定可以反映胶体溶液对超高龄患者心脏容量负荷的影响.
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