目的：探讨右旋美托咪定不同给药方式对小儿七氟醚麻醉后苏醒期躁动的影响。方法：选择2014年1月—11月在昆明市儿童医院行择期腭裂修补术的患儿90例，年龄2～7岁，美国麻醉医师协会（American Society of Anesthesiologists ，ASA ）分级Ⅰ～Ⅱ级，采用随机数字表法将患儿分为3组，每组各30例，其中D1组经静脉单次注射右旋美托咪定1μg／kg （10 min）负荷量，D2组静脉持续泵注右旋美托咪定1μg／（kg · h）至术毕，C组静脉持续泵注与D2组等容积0．9％氯化钠液作为对照；对比分析3组患儿镇静躁动评分及躁动发生率。结果：与C组比较，D1组、D2组镇静躁动评分、躁动发生率均降低（ P＜0．05）；D1组、D2组镇静躁动评分、躁动发生率比较差异均无统计学意义（ P＞0．05）。结论：右旋美托咪定单次负荷量静脉注射与静脉持续泵注均可有效降低小儿七氟醚麻醉后苏醒期躁动的发生，且二者效果类似。%Objective:To explore the effect of dexmedetomidine through different administration routes on emergence agitation after sevoflurane anesthesia in children .Methods:A total of 90 children aged from 2 years to 7 years ,who received scheduled cleft palate repair in Children’s Hospital of Kunming during Jan .2014 and Nov .2014 and were classified asⅠ by American Society of Anesthesiologists (ASA) criteria ,were selected and divided into 3 groups according to random number table with 30 in each group .Single loading dose of dexmedetomidine 1 μg/kg (10 min ) was intravenously injected in group D1 . And dexmedetomidine 1 μg/(kg · h) was intravenously pumped in group D2 till the operation was finished .In group C ,0 .9%normal saline was intravenously pumped with the same volume as that of dexmedetomidine in group D 2 .The sedation‐agitation scale scores as well as the incidence rates of agitation were compared among the three groups .Results:Compared with that in group C ,the sedation‐agitation scale scores and incidence rates of agitation in group D 1 and group D2 decreased (P<0 .05) .And there was no statistical difference regarding the sedation‐agitation scale score and incidence rate of agitation between group D 1 and group D2 .Conclusions :By both intravenous infusion with single loading dose and continuous intravenous pumping , dexmedetomidine can effectively reduce the incidence of emergence agitation after sevoflurane anesthesia in children .And both have a similar effect .
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