首页> 中文期刊> 《中国临床医学》 >5-氨基酮戊酸光动力疗法治疗中重度痤疮的疗效及安全性分析

5-氨基酮戊酸光动力疗法治疗中重度痤疮的疗效及安全性分析

         

摘要

目的::观察5-氨基酮戊酸光动力疗法(ALA-PDT)治疗中重度座疮的疗效。方法:将100例中重度座疮患者随机分为2组进行对照研究。ALA-PDT 组接受4次 ALA-PDT;异维 A 酸组予口服异维 A 酸胶囊10 mg,每日2次,同时外用阿达帕林凝胶治疗。疗效指数≥90%或治疗持续8周为研究终点。结果:ALA-PDT 组第4、8、12周末有效率分别为48%、74%、86%;而异维 A 酸组分别为36%、78%、88%。第12周末,ALA-PDT 组与异维 A 酸组的疗效无明显差异,但异维 A 酸组不良反应率较高。结论:ALA-PDT 治疗中重度座疮见效快,不良反应少。%Objective:To observe the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT)in the treatment of moderate to severe acne.Methods:One hundred patients with moderate to severe acne were randomly divided into 2 groups for the controlled study.The ALA-PDT group received 4 courses of ALA-PDT.The isotretinoin group was treated with oral administration of 10 mg Isotretinoin Capsules twice daily and external application of Adapalene Gel.The observation would be stopped when the efficacy index was higher than 90% or treatment continued for 8 weeks.Results:The effective rates 4,8 and 12 weeks later were 48%,74%,86% respectively in the ALA-PDT group,and 36%,78%,88% respectively in the isotretinoin group.There was no significant difference regarding the effective rate between the ALA-PDT group and the isotretinoin group by the end of the 12th week.However,the adverse reaction rate in the isotretinoin group was as high as 72%.Conclusions:In the treatment of moderate to severe acne,ALA-PDT shows fast onset and little adverse reaction.

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