目的：评价定量组织速度成像技术对检测家兔肺动脉栓塞模型右室功能的应用价值。方法家兔22只，经耳缘静脉注入栓子制成急性肺动脉栓塞模型。分别于造模前、造模后即刻、造模后1周及3周观察家兔右心室动态变化情况。存储心尖四腔心切面定量组织速度成像（ QTVI）图像并进行脱机分析。结果造模后即刻，右室游离壁基底段，中间段的收缩期峰值速度（ VP ）均较造模前明显减低，达峰时间（ TVp ）延长，三尖瓣口舒张早期峰值血流速度／舒张晚期峰值血流速度（Ve／Va）大于1。差别具有显著性意义（P＜0．05）。造模后1周，右室游离壁基底段，中间段的收缩期峰值速度（VP）均较造模前减低，达峰时间（TVp）延长，较造模后即刻组差别无显著性意义，但Ve／Va小于1。造模后3周，右室游离壁基底段，中间段的收缩期峰值速度（ VP ）较造模前仍减低， Ve／Va比值小于1。较造模后1周组差别具有显著性意义（ P＜0．05）。组内比较收缩期峰值速度，右室游离壁基底段均较中间段增大，差别具有显著性意义。但收缩期达峰时间，两者差别无显著性意义。结论定量组织速度成像能够直观反映家兔右室舒张及收缩功能状况，是评价动物肺动脉栓塞模型右室功能的重要手段。%Objective To evaluate the diagnostic value of quantitative tissue velocity imaging ( QTVI ) in the detection of right ventricle function in a rabbit model of pulmonary artery embolism .Methods Twenty-two healthy adult rabbits were used in this study .The animal models of acute pulmonary embolism were created by injecting gelatin sponge into the ear vein of rabbits .The changes of right ventricle function were dynamically observed at immediately , 1 week, and 3 weeks after the establishment of acute pulmonary embolims models .QTVI images of the 4-chamber view at cardiac apex were recorded and analyzed by off-line analysis.Results The VP was significantly reduced immediately after the models were built compared with the data before modeling in both the basal and middle segments , the TQ-S was prolonged , and Ve/Va>1 (P<0.05).The VP at1 week after modeling was not significantly decreased than the data before modeling in both the basal and middle segments , and the TQ-S was prolonged, but the Ve/Va ratio was <1 (P<0.05).At 3 weeks after modeling, the VPwas decreased compared with the data before modeling , and the Ve/Va ratio was <1 (P<0.05). The intra-group comparison showed that the V P of the basal segment of right ventricle free wall was enhanced than that of the middle segment (P<0.05), butTQ-S was not obviously prolonged in both the two segments .Conclusions Quantitative tissue velocity imaging can reflect the contraction and relaxation of right ventricle in rabbits precisely .It is a good method to evaluate the function of right ventricle in animal models of pulmonary artery embolism.
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