Objective To explore the differences in kronismus of Muc2 and DCN gene knockout mice. Methods Knockout homozygote males and females ( Muc2 -/ - ,DCN -/ - ) mice were mated respectively according to 1 :1 or 1 ;2 ratio. The average litter size of 1 - 3 generations, parity interval time, and kronismus in Muc2 and DCN gene knockout mice were observed. Results An average litter size of Muc2 gene knockout mice was 5.80 ±0.95. The average birth interval time was 42. 29 ±2. 28 days. The average DCN knockout mice seed production was 3. 85 ±0. 76, and the average birth interval time was 24. 86 ± 10. 42 days. There were significant differences between Muc2 and DCN gene knockout mice in the average litter size, parity interval time, and kronismus. Conclusions The reproductive performance of the two groups of gene knockout mice are different, indicating that Muc2 and DCN genes may be associated with reproductive function.%目的 探讨Muc2和DCN基因敲除小鼠繁殖能力和食子现象的异同.方法 分别将Muc2和DCN基因敲除纯合子雌雄小鼠按1∶1或1∶的合笼,观察1～3胎产仔量、胎次间隔时间、出生存活率和食子现象.结果 Muc2基因敲除小鼠平均产子量5.80±0.95只,平均胎次间隔时间(42.29±2.28) d;DCN基因敲除小鼠平均产子量3.85±0.76只,平均胎次间隔时间(24.86±10.42)d.Muc2和DCN基因敲除小鼠在产仔量、胎次间隔时间、出生存活率和食子率差异均存在显著性.结论 两组基因敲除小鼠繁殖性能有差异,揭示可能与Muc2和DCN基因有关.
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