目的 了解湖南省实验动物微生物学质量,为实验动物实行科学管理提供重要依据,保证实验动物质量,确保实验结果准确和实验动物科技事业工作者的职业健康与安全.方法 在相关单位生产繁殖群以单纯随机抽样原则采样,按照GB 14922.2-2001、GB/T 14926-2001和GB/T14926.21-2008进行实验动物微生物检测.结果 SPF级大鼠批次合格率为73.68％,SPF级小鼠批次合格率为77.78％,普通级新西兰兔批次合格率为60.61％,普通级豚鼠批次合格率为100％.结论 我省2006 ～2010年实验动物微生物学质量前期呈现下降趋势,后期得到较大改善.要继续采取措施加强实验动物管理,消除实验动物种群微生物感染.%Objective To know the laboratory animal's microbial quality in Hunan Province, and to provide the important basis for scientific management of experimental animals, to ensure the quality of laboratory animals, the experimental results and the occupational health and safety of animal science workers. Methods laboratory animals' microbiological test in accordance with GB 14922.2-2001 .GB/T 14926-2001 and GB/T 14926. 21-2008. Sample testing with the principle of simple random on the breeding colony in the relevant unit. Results SPP rat, SPF mice, Normal New Zealand rabbits, guinea pigs' batch qualified rate was 73. 68% , 77. 78% , 60. 61% andl00% respectively. Conclusions It is showed that microbiological quality of laboratory animals from 2006 to 2010 in Hunan province had a downward trend on the earlier stage, and had been improved greatly. Measures should be taken to strengthen the management of laboratory animals and to eliminate microbial infections in experimental animals.
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