目的:观察知柏地黄丸联合牙周基础治疗对2型糖尿病(T2DM)合并慢性牙周炎(CP)患者临床疗效的影响.方法:纳入T2DM合并CP患者60例,随机分为2组(n＝30).对照组行牙周基础治疗;观察组行牙周基础治疗+口服知柏地黄丸(8丸/次,3次/d)8周.分别于术前及术后8周,检查并记录龈沟出血指数(SBI)、探诊深度(PD)、附着丧失(AL);检测空腹血糖(FBG)、糖化血红蛋白(HbA1C)及稳态模型胰岛素抵抗指数(HOMA-IR),并用酶联免疫吸附法检测血清和龈沟液中肿瘤坏死因子-α(TNF-α)、白介素-6 (IL-6)、C-反应蛋白(CRP)的表达水平.结果:治疗8周后,观察组的牙周临床指标SBI、PD、AL及糖代谢指标FBG、HbA1C、HOMA-IR均较对照组有明显改善(P＜0.05);血清和龈沟液中炎症因子TNF-α、IL-6、CRP的表达水平均较对照组明显降低(P＜0.05).结论:知柏地黄丸联合牙周基础治疗可显著改善T2DM合并CP患者的牙周环境及血糖水平,其作用机制可能与抑制炎症因子的表达有关.%AIM:To investigate the influence of Zhibai Dihuang pills combined with basic periodontal treat-ment on clinical efficacy and inflammatory factors in patients with chronic periodontitis (CP)and type 2 diabetes (T2DM). METHODS:60 patients with T2DM and CP were randomly divided into 2 groups(n＝30). The patients in control group were treated with periodontal basic therapy,in test group with periodontal basic therapy and oral adminis-tration of Zhibaidihuang pills,8 pills tid for 8 weeks. Sulcus bleeding index (SBI),probing depth (PD),attachment loss (AL),fasting blood glucose (FBG),glycosylated hemoglobin (HbA1C),homeostasis model assessment of insu-lin resistance index (HOMA-IR),TNF-α,IL-6,and C- reactive protein (CRP)in serum and gingival crevicu-lar fluid were detected. RESULTS:SBI,PD,AL,FBG,HbA1C and HOMA-IR of the test group were significantly improved compared with those of control group (P＜0.05);TNF-α,IL-6 and CRP in serum and gingival crevicular fluid of the test group were significantly lower than those of the control group (P＜0.05). CONCLUSION:Zhibaidi-huang pill combined with periodontal treatment can significantly improve periodontal environment,glycemic control in patients with T2DM and CP,and its mechanism may be related to the inhibition of inflammatory factors.
展开▼
