Objective To compare ihe effecls of Conlinuous renal replacemenl iherapy combined wilh Abdominal Paracenlesis Lavage iherapy wilh Abdominal Paracenlesis Lavage iherapy on Abdominal comparlmenl syndrome (ACS). Methods A lolal of 52 ACS palienls were randomLy divided inlo Lwo groups. Combination iherapy group wilh 28 cases accepled CRRT and Abdominal Paracenlesis Lavage iherapy,and conlrol group wilh 24 cases only accepled ihe Abdominal Paracenlesis Lavage iherapy. The APACHE I and IRODS score ,lhe Blood lac lie acid, BNP, TNF - a, PCT, ihe function of liver and Kidney before and afler 24, 48, 72 hour Irealmenl, ihe fasling lime, ihe lime of bladder pressure dropped lo normal, lenglh of ICU slay and survival rale of ihe lwo groups were compared.Results The scores of combination iherapy group were significantly lower lhan ihose of conlrol group afler 48 - hour Lrealmenl, ihe fasling Lime, ihe Lime of bladder pressure dropped Lo normal and lengLh of ICU sLay of combinaLion Lherapy group were shorter, and survival raLe of combinaLion Lherapy group was higer( P < 0. 05 ) . Conclusion CRRT combined wiLh Abdominal ParacenLesis Lavage Lherapy would rapidly, effectively reduce abdominal pressure, proLecL organ funcLion, improve Lhe survival raLe.%目的 观察腹腔穿刺灌洗联合持续肾替代治疗(CRRT)与单纯腹腔穿刺灌洗治疗腹腔间隙综合征(ACS)效果.方法 选择52例ACS患者,随机分成两组,对照组为单纯腹腔穿刺灌洗组,联合治疗组同时行CRRT治疗,比较两组治疗前、治疗24、48、72 h后的急性生理和慢性健康状况评分(APACHEⅡ评分)、炎症反应器官功能不全评分(IRODS)、血乳酸、BNP、TNF-α、降钙素原(PCT)、肝肾功能、禁食时间、膀胱压降至正常时间、ICU治疗时间及出院存活率的差异.结果 联合治疗组治疗48 h后以上各项指标均明显优于对照组,同时联合治疗组禁食时间、膀胱压降至正常时间和ICU治疗时间均明显短于对照组,出院存活率明显高于对照组.结论 腹腔穿刺灌洗联合CRRT治疗较单纯腹腔穿刺灌洗治疗能更快、更有效地降低腹内高压、保护各脏器功能和提高存活率.
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