目的 研究活体肝移植患者围术期血清氨基末端-脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)的变化规律.方法 肝移植受者32例,静吸复合全麻下行活体部分肝移植术.分别于切皮前即刻(T0)、无肝期30 min(T1)、新肝期30 min(T2)、术毕(T3)、术后24 h(T4)和术后48 h(T5)采集中心静脉血样,检测血清NT-proBNP、肌钙蛋白I(cTnI)和肌酸激酶同工酶(CK-MB)浓度.结果 与T0时比较,T2~T5时血清NT-proBNP、cTnI浓度和CK-MB浓度显著升高(P<0.01,P<0.05).结论 活体肝移植患者围术期血清NT-proBNP浓度变化显著,从新肝期至术后48 h持续升高,提示肝移植围术期存在着一定程度的心肌损伤.%Objective To invesligale ihe characlerislics of serum N - terminal pro - brain nalriurelic peplide (NT - proBNP) in adulls undergoing living donor liver Lransplanlalion (LDLT). Methods 32 recipienls who underwent righl lobe adull - Lo - adull LDLT received general aneslhesia. Blood samples were drawn from cenlral vein before skin incision (To baseline) , al 30 min of anhepalic phase ( T, ) , 30 min of neohepalic phase ( T2) , ihe end of surgery ( T3 ) and 24, 48 h after operation ( T4 5 ) . Levels of NT - proBNP, cardiac Lroponin I ( cTnl) and crealine kinase MB ( CK - MB) were measured. Results The NT -proBNP, cTnl and CK - MB al T2 ~ T5 increased significanlly compared wilh Lhe baseline al To ( P < 0. 05, P < 0. 01 ). Conclusion The serum NT - proBNP increased significanlly in palienls undergoing LDLT from neohepalic phase lo firsl 48 h afler operation, which may imply some degree of myocardial injury caused by LDLT.
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