Objective To assess the perioperative levels of reticulocyte parameters (RTP) in peripheral blood of patients with liver transplantation. Methods The high fluorescence ratio(HFR), middle fluorescence ratio(MFR) and low fluorescence ra-tio (LFR) of peripheral reticulocytes were detected by Sysmex XE- 2100 automated hematology analyzer in 37 liver transplant re-cipients before and 20 d after surgery. ALT, AST, TP, TB, ALB, PT, INR and other liver function biochemical and coagulation pa-rameters before and after transplantation were measured. MELD score of patients was analyzed. Correlation of HFR, MFR, LFR with MELD score and liver function was analyzed. Results RET percentage on postoperative d5 recovered to the preoperative level, on d7 it was significantly higher than preoperative level (P<0.01) and it reached the peak on d10. Reticulocyte immature index IRF was increased from d1 after operation and reached the peak on d7. LFR and TB were positively correlated with MELD score, MFR, HFR;RET was negatively correlated with MELD score, however, MELD score was not correlated with AST, ALT, TP and ALB (P>0.05). ALT and AST significantly increased from d1 to d15 after transplantation (P<0.01);while there were no sig-nificant differences in ALB and TB levels before and after liver transplantation (P>0.05). Conclusion LFR, MFR, HFR and IRF are closely correlated with MELD score, indicating that reticulocyte parameters can be used as prognostic indicators for liver transplantation.%目的：检测外周血中高荧光强度网织红细胞比率（HFR）、中荧光强度网织红细胞比率（MFR）和低荧光强度网织红细胞比率（LFR）等在肝移植患者围术期的变化，探讨其在评价术后疗效中的价值。方法应用Sysmex XE-2100全自动血细胞分析仪定量检测37例肝移植受者术前、术后20d外周血中的HFR、MFR、LFR，评估HFR、MFR、LFR及网织红细胞（Ret）的变化；同时连续监测患者移植前后ALT、AST、TP、TB、ALB、PT、INR等肝功能生化及凝血功能指标，并在术前对患者进行肝移植终末期肝病模型（MELD）评分，评估HFR、MFR、LFR变化趋势及与MELD评分、肝功能变化趋势的相关性。结果 Ret百分比第5天升至移植前水平；术后第7天显著增高，第10天升至峰值；网织红细胞未成熟指数（IRF）移植后第1天高于移植前水平并呈上升趋势，第7天达到峰值；LFR、TB与MELD评分呈正相关，MFR、HFR、Ret与MELD评分呈负相关，而AST、ALT、TP、ALB与MELD评分无相关性（P＞0.05）。肝移植术后7d，ALB和TB与术前的差异无统计学意义（P＞0.05），而ALT、AST肝移植术后第1~15天显著升高（P＜0.05）。结论 LFR、MFR、HFR、IRF与MELD评分相关性良好，能对肝移植患者评估术后疗效提供参考。
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