交界性卵巢肿瘤(BOTs)占所有卵巢恶性肿瘤的15%~20%,具有不同于侵袭性卵巢癌(IOCs)的许多特征.BOTs的标准化治疗是进行彻底的全腹腔探查、全子宫切除术、双侧输卵管卵巢切除术、网膜切除术和腹腔冲洗液细胞学检查,并切除所有肉眼可见的可疑腹膜病变和多点腹膜活检;对于黏液性BOTs患者,应同时行阑尾切除术.BOTs通常发生于早期,多为年轻女性患者,并且相比IOCs患者具有优良的预后及较高的存活率.保留生育功能手术是年轻的BOTs患者的最佳治疗方法.这种保守性手术目前仍存在争议.手术后的妊娠和卵巢诱导以及体外受精也是重大问题.目前,暂不推荐术后化疗、放疗和激素治疗等辅助治疗.%Borderline ovarian tumors (BOTs) represent about 15% to 20% of all ovarian malignancies and differ from invasive ovarian cancers (IOCs) by many characters.Standardized treatment of BOTs is a complete abdominal exploration, hysterectomy, bilateral salpingo oophorectomy and omentectomy and peritoneal lavage cytology, and resection of all visible suspicious peritoneal lesions and multiple peritoneal biopsy;for mucinous BOTs patients should be underwent appendectomy.Because BOTs are often diagnosed at earlier stage, in younger age women and have better prognosis, higher survival rate than IOCs, fertility preserving surgery is the best treatment for young BOTs patients.The study of such conservative surgery is being released, and still controversial.After surgery, pregnancy and ovarian induction followed by in vitro fertilization are also significant issues.In surgery, laparoscopic technique can be used by a gynecologic oncology surgeon.So far, postoperative chemotherapy, radiotherapy and hormone therapy are not recommended.The paper discussed controversial issues of BOTs on this review and present the outline of the management of BOTs.
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