Objectvi e To investigate the relationship between coronary artery lesions and plasma fibrinogen (Fg). Methods From 2014 February to April , 91 cases of patients with suspected stable coronary artery disease were enrolled , based on the admission of basic clinical data , according to the results of coronary angiography , they were divided into non-cor-onary artery disease group of 21 cases, single vessel disease group of 37 cases, 2 lesions in 16 cases, 3 vessel or left main le-sion group in 17 cases.Fg, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL -C) were detected .Analyzed the relationship between plasma fibrinogen and coronary ar-tery disease.Results Compared with non-coronary artery disease group ,2-vessel group and 3-vessel or left main lesion group ’ s Fg levels were elevated,the differences were significant ( P<0 .05).Multivariate Logistic regression analysis showed:gen-der (OR=9.72, 95%CI 1.56-60.76, P =0.02), age (OR=1.09, 95%CI 1.00-1.17,P =0.04), TC (OR=10.87, 95%CI 1.56-762.4 , P =0.02), LDL-C (OR=1.06, 95%CI 1.01-1.50, P=0 .01), Fg (OR=74.0 ,95 %CI 1.82-30.03, P =0.01)were risk factors for coronary artery disease .Conclusion Gender, age, TC, LDL-C, Fg are risk factors for coronary artery disease , Fg level was increased in coronary artery disease patients , but the relationship with the severity of dis-ease is not determined yet .%目的：探讨血浆纤维蛋白原（ Fg）与冠状动脉病变之间的关系。方法2014年2-4月收治的拟诊稳定型冠心病患者91例，统计其入院基本临床资料，根据冠状动脉造影检查结果分为非冠心病组21例，单支病变组37例，2支病变组16例，3支或左主干病变组17例，均检测Fg、总胆固醇（ TC）、三酰甘油（ TG）、低密度脂蛋白胆固醇（ LDL-C）、高密度脂蛋白胆固醇（ HDL-C）。分析血浆纤维蛋白原与冠状动脉病变之间的关系。结果与非冠心病组比较，2支病变组、3支或左主干病变组Fg水平均升高，比较差异均有统计学意义（ P ＜0 f．05）。多因素Logistic回归分析显示：性别（OR＝9．72，95％CI 1．56～60．76， P ＝0．02）、年龄（OR＝1．09，95％CI 1．00～1．17， P ＝0．04）、TC（OR＝10．87，95％CI 1．56～76．24， P ＝0．02）、LDL -C（OR＝1．06，95％CI 1．01～1．50， P ＝0．01）、Fg（OR＝7．40，95％CI 1．82～30．03， P ＝0．01）是冠状动脉病变的危险因素。结论性别、年龄、TC、LDL-C、 Fg是冠状动脉病变的危险因素，冠状动脉病变后Fg水平可升高，尚不能肯定与病变程度有关。
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