Objective To observe the effect of Shensongyangxin capsule plus Tongxinluo capsule on cardiac electro-physiological properties in Japanese big ear rabbit with myocardial infarction model , and investigate the mechanism of treat-ment after myocardial infarction arrhythmia .Methods Twenty-four Japanese big ear rabbits were randomly divided into sham operation group and model group , Tongluo group with 8 rats in each group , before descending artery ligation to establish the model of myocardial infarction , Tongluo group were given 0.4 g· kg-1 · d-1 of Shensongyangxin powder +0.3 g· kg-1 · d-1 Tongxinluo powder through gastric lavage after the ligation of descending artery .After 8 weeks, in vivo electrophysiology were performed .Results Compared with the sham operation group , model group ’ s left ventricle adventitia myocardial cell action potential duration of 90%repolarization time (MAPD 90) is shortened ( P <0.05); left ventricular MAPD 90 also is shortened ( P <0.05);left ventricular effective refractory period (ERP) is prolonged ( P <0.05); ventricular fibrillation (VF) threshold (VFT) decreased significantly ( P <0.05).Compared with the model group,Tongluo group’s left ventricular adventitia myocardial cells MAPD 90 is prolonged;left ventricular MAPD 90 is prolonged ( P <0.05);ERP is shortened (P <0.05);VFT is increased significantly ( P <0.05).Conclusion The Shensongyangxin capsule plus Tongxinluo capsule could prolong MAPD 90 and shorten the ERP ,play the antiarrhythmic effect by increasing VFT after myocardial infarction .%目的：观察参松养心胶囊＋通心络胶囊对日本大耳兔心肌梗死模型心脏电生理特性的影响，并探讨其治疗心肌梗死后心律失常的机制。方法24只日本大耳兔随机分为假手术组、模型组、通络组各8只，以前降支动脉结扎术建立心肌梗死模型，通络组于结扎术后给予0�．4 g· kg-1· d-1参松养心原粉＋0．3 g· kg-1· d-1通心络原粉灌胃。8周后，行在体电生理研究。结果与假手术组比较，模型组左心室内、中、外膜层心肌细胞动作电位时限复极90％时间（MAPD90）缩短（ P ＜0．05）；左心室MAPD90缩短（ P ＜0．05）；左心室有效不应期（ERP）延长（ P ＜0．05）；心室颤动（室颤）阈值（VFT）明显降低（ P ＜0．05）。与模型组比较，通络组左心室内、中、外膜层心肌细胞MAPD90延长；左心室MAPD90延长（ P ＜0．05）；ERP缩短（ P ＜0．05）；VFT明显升高（ P ＜0．05）。结论参松养心胶囊联合通心络可延长MAPD90、缩短ERP，通过提高VFT发挥抗心肌梗死后心律失常的作用。
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