目的 观察阿魏酸钠辅治不稳定型心绞痛(UAP)的效果并探讨其作用机制.方法 将90例冠心病UAP患者随机分为治疗组60例,对照组30例,2组均常规使用硝酸酯类制剂、β受体阻滞剂、他汀类药物、抗栓剂,除应用上述常规治疗外,治疗组使用阿魏酸钠注射液静脉滴注;对照组使用复方丹参注射液静脉滴注,均用14d.观察2组疗效、主要症状、心电图及血hs-CRP、ET、LPO的情况.结果 治疗后治疗组疗效及心电图改善均优于对照组(分别为93.4% vs 83.3%和71.7% vs 33.4%,均P<0.05).治疗组血清hs-CRP、ET、LPO水平均较治疗前下降,且明显低于对照组(P<0.05),而对照组治疗后hs-CRP、ET显著降低,LPO差异无统计学意义(P>0.05).结论 阿魏酸钠辅治UAP疗效显著,是治疗冠心病UAP的一种有效药物.%Objective To explore the therapeutic effect and discuss the mechanism of sodium ferulate in patients with unstable angina pectoris ( UAP). Methods 90 patients with UAP were randomly divided into the treatment group of 60 cases , 30 patients in the control group. The patients in the treatment group were given sodium ferulate 300 mg by IV drip qd for 14 d, besides routine treatment. And the control group were given Danshen injection 20 ml by IV drip qd for 14d, in addition to the routine treatment. Observe the curative effect of two groups , the main symptoms , electrocardiogram and hs -CRP, ET, LPO changes. Results The treatment group was better than control group to improve the effect and electrocardiogram (93.4% vs 83.3% ,71.7% vs 33.4% , P <0. 05). Compared with the control group ,hs-CRP, ET, LPO level decreased in treatment group( P < 0. 05 ). in control group , hs-CRP and ET decreased ( P < 0. 05 ) , but LPO was not changed ( P > 0. 05 ). Conclusion Ferulic acid sodium could treat UAP effectively , which is an effective drug in treatment of UAP.
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