目的 探讨非瓣膜性心房颤动与C-反应蛋白(CRP)、纤维蛋白原(FIB)的关系及阿司匹林、稳心颗粒对其水平的影响.方法 应用速率散射比浊法定量测定102例非瓣膜性心房颤动(房颤组)患者和76例健康对照者(对照组)血清CRP、FIB 的浓度并进行比较;房颤组分为阿司匹林组(常规组52例)和阿司匹林联用稳心颗粒组(联合组50例),药物治疗3周后再次测定血清CRP、FIB浓度.结果 房颤组患者的CRP、FIB浓度明显高于健康对照组(P<0.01);联合组和常规组治疗后CRP较治疗前均明显降低(P<0.05),且联合组CRP、FIB均较常规组降低显著(P<0.05).结论 CRP和FIB在非瓣膜性房颤患者明显升高,是发生血栓栓塞并发症的一个重要参考指标;阿司匹林联用稳心颗粒可明显降低血清CRP、FIB浓度.%Objective To observe the effect of aspirin and Wenxin granule on the level of plasma C-reactive protein ( CRP ) and fibrinogen ( FIB ) in patients with non-valvular atrial fibrillation. Methods We detected the plasma FIB and CRP in 102 cases with non-valvular atrial fibrillation( fibrillation group ) by method of rate nephelometry, and then compared those index with 76 cases ( control group ) of healthy person. A comparative study was carried out on the level of plasma FIB and CRP in patients with atrial fibrillation after 3 weeks treatment with aspirin( routine group, n = 52 ) and Wenxin granule combined with aspirin( combination group, n = 50 ). Results It showed that the level of plasma FIB and CRP in patients with non-valvular atrial fibrillation group was significantly higher than that in control group( P ＜ 0.01 );the level of CRP and FIB declined obviously in routine group and combination group( P ＜ 0.05 ), and Cower in combination group than routine group ( P ＜ 0.05 ). Conclusion CRP and FIB can be used as indicators for detecting of pre thrombosis in patients with atrial fibrillation . It can decrease the level of CRP and FIB with use of aspirin and Wenxin granule.
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