目的：探讨颅内出血患者血清IL-6、TNF-α的水平变化及在法医学的临床意义。方法采用酶联免疫吸附法（ELISA）对颅内出血患者住院后不同时间段血清IL-6、TNF-α水平进行检测，并与正常对照组的健康受试者进行比较分析。结果研究组重型与轻型患者后第1、3、5、7天血清IL-6、TNF-α水平较正常对照组明显增加，重型患者入院第5、7天的血清IL-6、TNF-α较轻型患者明显增加，差异有统计学意义（P<0.05）；根据患者最后结果（死亡组和存活组），发现死亡组随着时间延长，在第5、7天时IL-6、TNF-α水平显著高于存活组（P<0.05）。此外，血清IL-6和TNF-α水平呈正性显著相关（r=0.721，P<0.05）。结论检测颅内出血患者血清IL-6、TNF-α水平对观察其病情变化有重要意义，可作为法医学鉴定的辅助手段。%Objective To explore the clinical significance of detecting serum levels of IL-6 and TNF-α in patients with intracranial hemorrhage.Methods The serum levels of IL-6 and TNF-α in different period were detected in patients with intracranial hemorrhage, by enzyme-linked immunosorbent assays (ELISA), and compared with those of healthy subjects (the control group).ResultsThe serum levels of IL-6, TNF-α in the severe and slight patients of study group on 1st, 3rd, 5th and 7th were signiifcantly higher than those in the control group (all withP<0.05). The serum levels of IL-6, TNF-α in the severe patients of study group were signiifcantly higher than those in slight patients of study group (all withP<0.05) on 5th and 7th. The serum levels of IL-6 and TNF-α in dead cases on 5th, 7th days admission were significantly higher than those in survival cases (P<0.05). The serum levels of IL-6 was positively correlated with TNF-α (r=0.721,P<0.05).Conclusion The detection of dynamically serum levels of IL-6 and TNF-α is of great clinical value for assessing the disease development therapeutic efifcacy and prognosis of brain injury patient with intracranial hemorrhage.
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