Objective To investigate the effect of hyperbaric oxygen therapy on pain and cognitive function of patients with sleep disorder and anxiety and depression after moderate and severe traumatic brain injury. Method From June 2014 to June 2016, 86 patients with sleep disorders associated with anxiety and depression after moderate and severe traumatic brain injury in our hospital were selected, they were divided into study group (43 cases) and control group (43 cases) in different therapeutic method. Control group patients were treated with conventional drugs and psychological intervention according to their sleep disorder, anxiety and depression severity, study group patients were treated with hyperbaric oxygen therapy on the basis of control group, and 3 courses of treatment in two groups. Before treatment, 7 days and 10 days after treatment, the cognitive function of the two groups were evaluated by Loewenstein occupational therapy cognitive assessment (LOTCA), and the degree of pain was evaluated by visual analogue scale (VAS). Result After treatment, the score LOTCA of the two groups were significantly higher than those before treatment (P<0.05), the total score of LOTCA and each dimension scores of study group were significantly higher than control group (P<0.05), 7 days and 10 days after treatment, the VAS scores of the two groups were significantly lower than those before the treatment (P<0.05), the VAS score of study group was significantly lower than that of control group (P<0.05). Conclusion Hyperbaric oxygen therapy can not only protect the neurological function of patients with traumatic brain injury, but also relieve the pain degree of moderate and severe traumatic brain injury patients with sleep disorders accompanied by anxiety and depression, improve their cognitive function, and further improve the prognosis of patients with moderate and severe traumatic brain injury.%目的 探讨高压氧治疗对中、重度颅脑损伤后睡眠障碍伴焦虑和抑郁患者的疼痛及认知功能的影响.方法 选择2014年6月至2016年6月本院收治的中、重度颅脑损伤后睡眠障碍伴焦虑和抑郁患者86例为研究对象,根据治疗方式不同将其分为研究组和对照组,每组各43例.对照组患者由精神科医生会诊后根据其睡眠障碍及焦虑和抑郁严重程度采用常规药物及心理干预.研究组患者在对照组治疗基础上给予高压氧治疗.采用洛文斯顿作业疗法认知功能评定量表(Loewenstein occupational therapy cognitive assessment,LOTCA)评价两组患者的认知功能,采用视觉模拟评分法(visual analogue scale, VAS)评价两组患者治疗前、治疗7天及10天后的疼痛程度.结果 治疗后,两组患者LOTCA总分均显著高于治疗前(P<0.05),研究组患者LOTCA总分和各维度评分均显著高于对照组(P<0.05).治疗7天和10天后,两组患者VAS评分均显著低于治疗前(P<0.05),且研究组患者VAS评分均显著低于对照组(P<0.05).结论 高压氧治疗不仅可保护颅脑损伤患者的神经功能,还可减轻中、重度颅脑损伤后睡眠障碍伴焦虑和抑郁患者的疼痛程度,改善其认知功能和预后.
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