Objective To analyze the clinical effect and the immune function of Montelukast sodium in the treatment of recurrent wheezing after bronchiolitis in children, and to explore its clinical application value. Method 214 cases of children with bronchiolitis repeated wheezing in Children's Hospital of Hebei Province, the First Affiliated Hospital of Hebei Medical University, Tangshan City Maternal and Child Health Care Hospital from August 2015 to July 2016 were selected as the research objects. They were randomly divided into observation group and control group, 107 cases ineach group. All of the children were given conventional treatment, observation group children were treated with Montelukast sodium. The clinical symptoms improved after 1 week treatment, changes of immune function before and after treatment and wheezing episodes 6 months after treatment were compared between the two groups.Result The clinical symptoms improvement time and hospitalization time of observation group were shorter than those of control group (P<0.05), and the total effective rate of observation group was higher than that of control group (P<0.05). No treatment related adverse reactions occurred in the two groups during the treatment period. The serum levels of interleukin(IL)-17 and immunoglobulin (Ig) E were significantly decreased in the two groups after 3 months treatment (P<0.05). The level of interferon-γ (IFN-γ) was significantly higher than before treatment, and the changes in observation group were more significant (P<0.05). The recurrence rate of recurrent wheezing in observation group was significantly lower than that in control group (χ2=5.318,P<0.05).Conclusion On the basis of conventional therapy combined with Montelukast sodium, it can improve the immune function of children while it is safe, to alleviate the clinical symptoms, reduce the risk of recurrent wheezing and improve the overall treatment effect.%目的 分析孟鲁司特钠对毛细支气管炎急性发作后反复喘息的临床效果及其对患儿免疫功能的影响,探讨其临床应用价值.方法 选取河北省儿童医院、河北医科大学附属第一医院、唐山市妇幼保健院2015年8月至2016年7月收治的214例毛细支气管炎急性发作后反复喘息患儿为研究对象.按照随机数表法将入选患儿分为观察组与对照组,每组各107例.所有患儿均给予常规综合治疗,观察组患儿加用孟鲁司特钠治疗.比较两组患儿治疗1周后临床症状改善时间、治疗前后免疫功能变化情况及治疗后6个月内喘息发作情况.结果 观察组患儿各项临床症状改善时间及住院天数均短于对照组(P<0.05),临床总有效率高于对照组(P<0.05).治疗3个月后两组患儿血清白介素-17和免疫球蛋白E水平较治疗前均显著降低(P<0.05),γ-干扰素水平较治疗前均显著升高(P<0.05);观察组患儿上述指标变化更显著(P<0.05).观察组患儿反复喘息复发率显著低于对照组(χ2=5.318,P<0.05).结论 在常规综合治疗基础上联合应用孟鲁司特钠,能够在保证安全性的同时进一步改善毛细支气管炎急性发作后反复喘息患儿的免疫功能,缓解临床症状、降低喘息复发风险,提高整体治疗效果.
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