Objective To explore the application of dimethicone powder in bowl preparation before colonoscopy.Methods We conducted a systematical research by randomized controlled trial (RCT) on 642 sample patients selected continuously who underwent colonoscopy in our hospital from February, 2009 to February, 2010. The samples were divided into experimental group and control group, 321 patients in each group. Patients in the experimental group took 50 mL 30％ magnesium sulfate and 300 mg dimethicone powder before colonoscopy. Patients in the control group took 50 mL 30％ magnesium sulfate without taking dimethicone powder. The enteric cleanliness, the amount of bubbles in the enteric cavity and the seriousness of bubbles in the intestinal tract were observed. The patients in both groups showed higher degrees of enteric cleanliness, and there was no significant difference ( P ＞ 0.05 ). The experimental group showed better effect of defoaming, and there was statistically different (P ＜0.01 ). Compared with control group, the seriousness of bubbles was lower in experimental group, and there was the statistically significant difference ( P ＜ 0.01 ). Conclusion The study shows that the dimethicone powder has a better effect of defoaming, it should be used in the bowel preparation before colonoscopy.%目的 研究二甲硅油散在结肠镜检查前肠道准备中的应用.方法 对本院消化内镜中心2009年2月～2010年2月结肠镜检查患者连续选择642例进行前瞻、随机、对照系统研究.根据肠道准备方案的不同将研究对象随机分成实验组和对照组,各321例.实验组在结肠镜检查前口服30%硫酸镁50 mL+二甲硅油散300 mg,对照组则口服30%硫酸镁50 mL而不服用二甲硅油散直接进行结肠镜检查.观察两组患者肠道清洁程度、肠腔气泡程度、肠道严重气泡率.结果 两组患者的肠道清洁满意率均较高,两组比较差异无统计学意义(P>0.05);实验组祛泡效果较好,两组比较差异有统计学意义(P<0.01).实验组肠道严重气泡率明显低于对照组,两组比较差异有统计学意义(P＜0.01).结论 本组研究发现实验组取得了较高的祛泡满意率和较低的严重气泡率,表明口服二甲硅油散具有较好的祛泡效果,适合广泛应用于结肠镜检查前的肠道准备中.
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